Grignard cyclization reaction of fluorinated N-arylimidoyl chlorides:: A novel and facile access to 2-fluoroalkyl indoles

被引：24

作者：

Ge, Fenglian

Wang, Zengxue

Wan, Wen

Hao, Jian

机构：

[1] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

来源：

SYNLETT | 2007年 / 03期

关键词：

fluorine-containing indoles; Grignard cyclizations; imidoyl chlorides; aryl amines; heterocycles;

D O I：

10.1055/s-2007-967950

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Fluoroalkyl-substituted indole derivatives were simply prepared via the Grignard cyclization reaction (GCR) of corresponding fluorinated N-aryl imidoyl chlorides in good yields. This approach provides a novel and facile access to the biologically important 2-fluoroalkylindole derivatives.

引用

页码：447 / 450

页数：4

共 6 条

[1] Pd-Catalyzed Deacylative [4+1] Annulation of N-Arylimidoyl Chlorides with β-Keto Esters Leading to 2-Fluoroalkyl Indoles
Li, Na
Zhao, Zhi-Yi
Huang, Zi-Han
Shao, Yu-Kai
Wang, Zhao-Lun
Tu, Hai-Yong
Zhang, Xing-Guo
JOURNAL OF ORGANIC CHEMISTRY, 2024, 89 (18): : 13795 - 13799
[2] Fluorinated N-[2-(haloalkyl)phenyl]imidoyl chloride, a key intermediate for the synthesis of 2-fluoroalkyl substituted indole derivatives via Grignard cyclization process
Wang, Zengxue
Ge, Fenglian
Wan, Wen
Jiang, Haizhen
Hao, Jian
JOURNAL OF FLUORINE CHEMISTRY, 2007, 128 (10) : 1143 - 1152
[3] α-Nitrosostyrenes as Three-Atom Units for the (3+1) Cyclization Reaction: Facile Access to 2,3-Dihydrodiazete N-Oxides and Their Diversified Synthetic Conversions
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[4] A bench-stable low-molecular-weight vinyl azide surrogate for a cascade reaction: facile access to novel N-vinyl-1,2,3-triazoles
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Wang, Lianxiao
Yu, Tian
Sun, Yanan
Chen, Huimin
Gao, Wen
Tang, Bo
ORGANIC CHEMISTRY FRONTIERS, 2020, 7 (18): : 2628 - 2633
[5] A bench-stable low-molecular-weight vinyl azide surrogate for a cascade reaction: Facile access to novel: N -vinyl-1,2,3-triazoles
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Wang, Lianxiao
Yu, Tian
Sun, Yanan
Chen, Huimin
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Tang, Bo
Gao, Wen (gaowen@sdnu.edu.cn); Tang, Bo (tangb@sdnu.edu.cn), 1600, Royal Society of Chemistry (07): : 2628 - 2633
[6] Reaction of Ethyl 5-Acetyl-3,4-dihydropyridine-1(2H)-carboxylate with 1,3-N,N-Bis-nucleophiles: A Facile Access to Novel Pyrimidine Derivatives
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Mykhailiuk, Pavel K.
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