Effect of recombinant basic fibroblast growth factor (bFGF) on fibroblast-like cells from human rotator cuff tendon

被引：33
|
作者：
Takahashi, S [1 ]
Nakajima, M [1 ]
Kobayashi, M [1 ]
Wakabayashi, I [1 ]
Miyakoshi, N [1 ]
Minagawa, H [1 ]
Itoi, E [1 ]
机构：
[1] Akita Univ, Sch Med, Dept Orthoped Surg, Akita 0108543, Japan
来源：
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 2002年 / 198卷 / 04期
关键词：
basic fibroblast growth factor; rotator cuff tendon; collagen; proliferation; primary culture;
D O I：
10.1620/tjem.198.207
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Rotator cuff tendon cells (RCC) derived from surgical samples showed fibroblast-like morphology. Histological staining demonstrated collagen secretion by RCC. Immunohistological findings revealed that RCC secreted type I and III collagen, but not type II collagen. In addition, the SDS-PAGE analysis suggested that RCC predominantly produced type I collagen. Basic fibroblast growth factor (bFGF) had a stimulatory effect on the proliferation of RCC dose-dependently up to 1 ng/ml. Administration of bFGF suppressed the secretion of collagens from RCC in a dose-dependent manner. - basic fibroblast growth factor; rotator cuff tendon; collagen; proliferation; primary culture (C) 2002 Tohoku University Medical Press.
引用
收藏
页码：207 / 214
页数：8
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