The novel economical synthesis and antimicrobial activity of a trithiocarbonate derivative

被引：4

作者：

Mabkhot, Yahia N. ^{[1
]}

Khaled, Jamal M. A. ^{[2
]}

Sultan, Mujeeb A. S. ^{[3
,4
]}

Alharbi, Naiyf S. H. A. ^{[2
]}

Al-Showiman, Salim S. ^{[5
]}

Ghabbour, Hazem A. ^{[6
]}

Alsayari, Abdulrahman ^{[7
]}

Bin Muhsinah, Abdullatif ^{[7
]}

Algarni, H. ^{[8
,9
]}

机构：

[1] King Khalid Univ, Coll Pharm, Dept Pharmaceut Chem, Abha, Saudi Arabia

[2] King Saud Univ, Coll Sci, Dept Bot & Microbiol, Riyadh, Saudi Arabia

[3] Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia

[4] Aljanad Univ, Fac Med Sci, Dept Pharm, Raiz, Yemen

[5] King Saud Univ, Sci Coll, Dept Chem, POB 2455, Riyadh, Saudi Arabia

[6] Univ Mansoura, Fac Pharm, Dept Med Chem, Mansoura 35516, Egypt

[7] King Khalid Univ, Coll Pharm, Dept Pharmacognosy, Abha, Saudi Arabia

[8] King Khalid Univ, Fac Sci, Dept Phys, POB 9004, Abha, Saudi Arabia

[9] King Khalid Univ, RCAMS, POB 9004, Abha 61413131413, Saudi Arabia

来源：

BIOORGANIC CHEMISTRY | 2019年 / 91卷

关键词：

Antimicrobial activity; Diethyl 2,2 ' (thiocarbonyl bis (sulfanediyl)); diacetate; Synthesis; Trithiocarbonate; ANHYDRASE INHIBITORS. INHIBITION; ANTIFUNGAL AGENTS; XANTHATES;

D O I：

10.1016/j.bioorg.2019.103157

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The compound diethyl 2,2'-(thiocarbonyl-bis(sulfanediyl))-diacetate 4 belongs to the trithiocarbonate class containing a trithiocarbonate function group flanked by ethyl acetate. In this procedure, a novel economic synthesis route to obtain compound 4 is described. This compound proved to possess broad-spectrum antimicrobial activity both in vitro and in vivo, and could be used as a lead compound. It is worth mentioning that this compound has been patented [No. US 9,988,348 B1; date of patent: June 5, 2018].

引用

页数：9

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