Nickel-Catalyzed Cross-Electrophile Coupling Reactions between Allylic Acetates and gem-Difluorovinyl Tosylate

被引：3

作者：

He, Xiaochun ^{[1
,2
,3
]}

Liu, Jiangjun ^{[1
,2
,3
]}

Chen, Gang ^{[1
,2
,3
]}

Xiong, Baojian ^{[1
,2
,3
]}

Xiao, Xue ^{[1
,2
,3
]}

Chen, Lei ^{[1
,2
,3
]}

Zhang, Xuemei ^{[1
,2
,3
]}

Dong, Lin ^{[1
,2
,3
]}

Ma, Xuelei ^{[1
,2
,3
]}

Lian, Zhong ^{[1
,2
,3
]}

机构：

[1] Sichuan Univ, West China Sch Pharm, West China Hosp, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, State Key Lab Biotherapy, West China Hosp, Chengdu 610041, Sichuan, Peoples R China

[3] Sichuan Univ, Canc Ctr, West China Hosp, Chengdu 610041, Sichuan, Peoples R China

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 19期

基金：

中国国家自然科学基金;

关键词：

DIAZO-COMPOUNDS; DIFLUOROOLEFINATION; GENERATION; HALIDES; TMSCF3; ZINC;

D O I：

10.1021/acs.orglett.2c01245

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A nickel-catalyzed cross-electrophile coupling of allylic acetates and gem-difluorovinyl tosylate is presented, which first achieves allylic gem-difluoroolefins via C(sp(3))-C(sp(2)) cross-electrophile coupling. In addition, this protocol was performed under mild reaction conditions, affording a variety of allylic gem-difluorovinyl arenes in moderate to good yields. Moreover, both linear and branched allylic acetate could produce a linear cross-coupling product exclusively. Mechanistic studies reveal that the reaction involves two different Ni(0)/Ni(II) catalytic cycles.

引用

页码：3538 / 3543

页数：6

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