The co-epidemics of HIV and Violence Against Women and Girls (VAW&G) are raging out of control. Women, girls, and even female infants face unimaginable risk for HIV through violent means. Rape, Domestic Violence and sex trafficking have become vectors of HIV and have become a pivotal part of the transmission cycle. With limited human and financial resources, new, innovative and collaborative approaches on a massive scale are called for. This paper will show how to build on the powerful work being done in HIV, Violence Against Women and Girls, and related fields such as human rights, public health, prostitution, trafficking, reproductive rights, economic parity, etc., to develop multi-disciplinary nationwide Coalitions on a scale never before attempted. Representing vast numbers of constituents, Intersect Coalitions engage in cooperative action, raise awareness, innovate approaches to education, law, and public policy and marshal a highly visible and vocal force to affect significant change in the lives of those impacted by violence and HIV.