Cell death induced by Pteris semipinnata L. is associated with p53 and oxidant stress in gastric cancer cells

被引：27
|
作者：
Liu, ZM
Ng, EKW
Liang, NC
Deng, YF
Leung, BCS
Chen, GG [1 ]
机构：
[1] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Surg, Shatin, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Prince Wales Hosp, Sir YK Pao Ctr Canc, Shatin, Hong Kong, Peoples R China
[3] Guangdong Med Coll, Inst Biochem & Mol Biol, Zhanjiang, Guangdong, Peoples R China
来源：
FEBS LETTERS | 2005年 / 579卷 / 06期
关键词：
gastric cancer; p53; glutathione; cytotoxicity; apoptosis; Pteris semipinnata L;
D O I：
10.1016/j.febslet.2005.01.050
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this study, we demonstrated that Ent-11alpha-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F) had stronger cytotoxicity against MKN-45, a gastric cancer cell line bearing wild-type p53 than MKN-28, another gastric cancer cell line containing missense mutation in p53. The rapid increase of ROS level was involved in the mechanism of cytotoxicity. Classical features of apoptosis induced by 5F were observed in MKN-45 cells only or more significant in MKN-45 cells than MKN-28 cells. Translocation of Bax from cytosol to mitochondria, reduction of Deltapsim and DNA fragmentation were induced by 5F in the p53-dependent manner. We conclude that the expression of Bax and its downstream molecules requires the presentation of a wild-type p53 in the cells treated by 5F. (C) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1477 / 1487
页数：11
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