Insecticide resistance in mosquito vectors

被引：371
|
作者：
Weill, M
Lutfalla, G
Mogensen, K
Chandre, F
Berthomieu, A
Berticat, C
Pasteur, N
Philips, A
Fort, P
Raymond, M
机构：
[1] Univ Montpellier 2, Inst Sci Evolut, UMR 5554, F-34095 Montpellier, France
[2] CNRS, Def Antivirales & Tumorales UMR 5124, F-34293 Montpellier, France
[3] CNRS, Ctr Rech Biochim Macromol, UPR1086, F-34293 Montpellier, France
[4] IRD, LIN, F-34394 Montpellier, France
来源：
NATURE | 2003年 / 423卷 / 6936期
关键词：
D O I：
10.1038/423136b
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Resistance to insecticides among mosquitoes that act as vectors for malaria (Anopheles gambiae) and West Nile virus (Culex pipiens) emerged more than 25 years ago in Africa, America and Europe; this resistance is frequently due to a loss of sensitivity of the insect's acetylcholinesterase enzyme to organophosphates and carbamates1. Here we show that this insensitivity results from a single amino-acid substitution in the enzyme, which we found in ten highly resistant strains of C. pipiens from tropical (Africa and Caribbean) and temperate (Europe) areas, as well as in one resistant African strain of A. gambiae. Our identification of this mutation may pave the way for designing new insecticides.
引用
收藏
页码：136 / 137
页数：2
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