A novel dimeric podophyllotoxin-type lignan and a new withanolide from Withania coagulans

被引：14
|
作者：
Nur-e-Alam, M [1 ]
Yousaf, M [1 ]
Qureshi, S [1 ]
Baig, I [1 ]
Nasim, S [1 ]
Atta-ur-Rahman [1 ]
Choudhary, MI [1 ]
机构：
[1] Univ Karachi, Int Ctr Chem Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan
来源：
HELVETICA CHIMICA ACTA | 2003年 / 86卷 / 03期
关键词：
D O I：
10.1002/hlca.200390060
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel dimeric lignan, bispicropodophyllin glucoside (1) and a highly oxygenated new withanolide, coagulin S (2) were isolated from the ethanolic extract of Withania coagulans. The structures were established on the basis of the spectroscopic data and have been identified as (5S*,5aR*,8aR*,9S*,15S*,15aS* 18aS*,19S*)-,9,19-di-beta-D-glucopyranosyl-5,8a,9,15,15a,18,18a,19-octahydro-5,15-bis(3,4,5-trimethoxyphenyl)bis([1,3]dioxolo-[4',5':6,7]naphtho)[2,3-c:2,3-h][1,6]dioxecin-6,16(5aH,8H)-dione (1) and (20S*,22R*)-5alpha,6beta,14alpha,15alpha,17beta,20,27-heptahydroxy-1-oxowith-24-enolide (2), respectively.
引用
收藏
页码：607 / 614
页数：8
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