Low-Level Viremia Early in HIV Infection

被引：11

作者：

Chen, Iris ^{[1
]}

Cummings, Vanessa ^{[1
]}

Fogel, Jessica M. ^{[1
]}

Marzinke, Mark A. ^{[1
]}

Clarke, William ^{[1
]}

Connor, Matthew B. ^{[2
]}

Griffith, Sam ^{[3
]}

Buchbinder, Susan ^{[4
]}

Shoptaw, Steven ^{[5
]}

del Rio, Carlos ^{[6
]}

Magnus, Manya ^{[7
]}

Mannheimer, Sharon ^{[8
]}

Wheeler, Darrell P. ^{[9
]}

Mayer, Kenneth H. ^{[10
]}

Koblin, Beryl A. ^{[11
]}

Eshleman, Susan H. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[2] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA

[3] FHI 360, Sci Facilitat Dept, Res Triangle Pk, NC USA

[4] Bridge HIV, San Francisco Dept Publ Hlth, San Francisco, CA USA

[5] Univ Calif Los Angeles, Dept Family Med, Los Angeles, CA USA

[6] Emory Univ, Rollins Sch Publ Hlth, Dept Global Hlth, Atlanta, GA 30322 USA

[7] George Washington Univ, Dept Epidemiol & Biostat, Washington, DC USA

[8] Columbia Univ, Dept Med, Harlem Hosp, Mailman Sch Publ Hlth, New York, NY USA

[9] Loyola Univ, Grad Sch Social Work, Chicago, IL 60611 USA

[10] Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Med,Med Sch, Fenway Inst,Fenway Hlth Infect Dis Div, Boston, MA 02215 USA

[11] New York Blood Ctr, Lab Infect Dis Prevent, Lindsley F Kimball Res Inst, New York, NY 10021 USA

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2014年 / 67卷 / 04期

基金：

美国国家卫生研究院;

关键词：

HIV; seroconversion; viral load; HIV controllers; diagnosis; VIRAL CONTROL; RESISTANCE; REPLICATION; PERFORMANCE; PROGRESSION; DIAGNOSIS; LOAD;

D O I：

10.1097/QAI.0000000000000298

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV RNA levels are usually high early in HIV infection. In the HPTN 061 study, men were tested for HIV infection every 6 months; 6 (21.4%) of 28 men who acquired HIV infection during the study had low or undetectable HIV RNA at the time of HIV diagnosis. Antiretroviral drugs were not detected at the time of HIV diagnosis. False-negative HIV test results were obtained for 2 men using multiple assays. Antiretroviral drug resistance mutations were detected in HIV from 1 man. Additional studies are needed to identify factors associated with low HIV RNA levels during early HIV infection.

引用

页码：405 / 408

页数：4

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