Anti-angiogenic agents for the treatment of brain tumors

被引：10
|
作者：
Fisher, MJ
Adamson, PC
机构：
[1] Childrens Hosp Philadelphia, Div Clin Pharmacol & Therapeut, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Philadelphia, PA 19104 USA
[3] Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA USA
来源：
NEUROIMAGING CLINICS OF NORTH AMERICA | 2002年 / 12卷 / 04期
关键词：
D O I：
10.1016/S1052-5149(02)00035-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The importance of angiogenesis, the formation of new blood vessels from pre-existing ones, has been recognized for more than 30 years. Many primary brain tumors appear to be angiogenesis dependent. Preclinical and clinical studies suggest that angiogenesis inhibition may be a promising new treatment strategy for brain tumors. This article reviews the biology of angiogenesis and its role in brain tumors, discusses antiangiogenic agents in clinical trials, and presents neuroimaging approaches to the study of the angiogenic process and its inhibition.
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页码：477 / +
页数：24
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