Photoredox-catalyzed oxytrifluoromethylation of allenes: stereoselective synthesis of 2-trifluoromethylated allyl acetates

被引：31
|
作者：
Tomita, Ren [1 ]
Koike, Takashi [1 ]
Akita, Munetaka [1 ]
机构：
[1] Tokyo Inst Technol, Inst Innovat Res, Lab Chem & Life Sci, Midori Ku, R1-27,4259 Nagatsuta Cho, Yokohama, Kanagawa 2268503, Japan
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 34期
关键词：
ELECTROPHILIC TRIFLUOROMETHYLATING REAGENTS; DIASTEREOSELECTIVE SYNTHESIS; FLUOROALKYLATION REACTIONS; SUBSTITUTION-REACTION; AROMATIC ALKENES; DONOR ABILITIES; RECENT PROGRESS; EFFICIENT; ALKYNES; BONDS;
D O I：
10.1039/c7cc01759f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We have developed novel oxytrifluoromethylation of aryl-substituted allenes by photoredox catalysis. The present photocatalytic system allows direct and stereoselective synthesis of 2-CF3- allyl acetates bearing tetrasubstituted CF3-alkene scaffolds in a single operation. The obtained CF3-allyl acetates can be applied to further functionalization as CF3-containing building blocks.
引用
收藏
页码：4681 / 4684
页数：4
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