Synthesis and X-ray diffraction study of 5-(8-methoxy-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinolin-1-yl)-1,3-dimethylbarbituric acid

被引：0

作者：

Krasnov, KA

Kartsev, VG

Khrustalev, VN

机构：

[1] II Mechnikov St Petersburg State Med Acad, St Petersburg 195067, Russia

[2] INTERBIOSCREEN Joint Stock Co, Chernogolovka 143432, Moscow Region, Russia

[3] Russian Acad Sci, AN Nesmeyanov Organoelement Cpds Inst, Moscow 119991, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2003年 / 52卷 / 03期

关键词：

cotarnine; 1,3-dimetliylbarbituric acid; 5-(8-methoxy-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinolin-1-yl)-1,3-dimethylbarbituric acid; X-ray diffraction analysis; NMR spectroscopy;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction of cotarnine with 1,3-dimethylbarbituric acid afforded 5-(8-methoxy-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinolin-1-yl)-1,3-dimethylbarbituric acid. Its crystal structure was established by X-ray diffraction analysis and the structure in solution was studied by H-1 NMR spectroscopy. This compound has a zwitterionic structure. In the crystal, the molecules are linked in dimers by intermolecular hydrogen bonds, and in solutions, the dimers occur in equilibrium with the monomers.

引用

页码：705 / 709

页数：5

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