Research Progress in Structural Modification of Antimycin A

被引：3
|
作者：
Cheng, Hua [1 ]
Nie, Ren [1 ]
Wang, Wangqiang [1 ]
Huang, Lin [1 ]
Liu, Ke [1 ]
Chen, Cheng [3 ]
Wu, Qiongyou [2 ]
机构：
[1] Hubei Univ Arts & Sci, Dept Chem Engn & Food Sci, Xiangyang 441053, Peoples R China
[2] Cent China Normal Univ, Coll Chem, Key Lab Pesticide Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China
[3] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Hubei, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 37卷 / 06期
基金：
中国国家自然科学基金;
关键词：
antimycin A; inhibitor; biological activity; structural modification; 1ST TOTAL-SYNTHESIS; ELECTRON-TRANSPORT; POTENT INHIBITORS; ANTIBIOTICS; CHEMISTRY; ANALOGS; COMPLEX; BINDING; COMPONENTS; SEPARATION;
D O I：
10.6023/cjoc201702010
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Antimycin A is a class of natural products bearing a dilactone-ring moiety as the core skeleton. These compounds have been identified as specific inhibitors of the mitochondrial respiratory chain and bind to the Q(i) site of the cytochrome bc(1) complex. Due to its unique structure and extremly high activity, it has aroused great interest of researchers. The development and biological activities of antimycin A are mainly described, and the recent results of its structural modifications are summarized.
引用
收藏
页码：1368 / 1381
页数：14
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