Metformin as Anti-Aging Therapy: Is It for Everyone?

被引：157
|
作者：
Soukas, Alexander A. [1 ,2 ,3 ,4 ]
Hao, Haibin [5 ,6 ]
Wu, Lianfeng [5 ,6 ]
机构：
[1] Massachusetts Gen Hosp, Dept Med, Diabet Unit, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 USA
[3] Harvard Med Sch, Dept Med, Boston, MA 02115 USA
[4] Broad Inst Harvard & MIT, Cambridge, MA 02142 USA
[5] Westlake Univ, Westlake Inst Adv Study, Inst Basic Med Sci, Hangzhou 310024, Zhejiang, Peoples R China
[6] Westlake Univ, Sch Life Sci, Hangzhou 310024, Zhejiang, Peoples R China
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2019年 / 30卷 / 10期
关键词：
ACTIVATED PROTEIN-KINASE; EXTENDS LIFE-SPAN; C.-ELEGANS; BINDING PROPERTIES; CELL-GROWTH; RAG GTPASES; RAPAMYCIN; COMPLEX; GLUCONEOGENESIS; DEFICIENCY;
D O I：
10.1016/j.tem.2019.07.015
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Metformin is the most widely prescribed oral hypoglycemic medication for type 2 diabetes worldwide. Metformin also retards aging in model organisms and reduces the incidence of aging-related diseases such as neurodegenerative disease and cancer in humans. In spite of its widespread use, the mechanisms by which metformin exerts favorable effects on aging remair largely unknown. Further, not all individuals prescribed metformin derive the same benefit anc some develop side effects. Before metformin finds its way to mainstay therapy for anti-aging, c more granular understanding of the effects of the drug in humans is needed. This review pro vides an overview of recent findings from metformin studies in aging and longevity and discusses the use of metformin to combat aging and aging-related diseases.
引用
收藏
页码：745 / 755
页数：11
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