Bone marrow-derived endothelial progenitor cells for vascular regeneration

被引：0
|
作者：
Murayama, T
Asahara, T
机构：
[1] St Elizabeths Med Ctr, Div Cardiovasc Res, Brighton, MA 02135 USA
[2] RIKEN, Ctr Dev Biol, Kobe Inst Biomed Res & Innovat, Chuo Ku, Kobe, Hyogo 6500047, Japan
[3] Tokai Univ, Sch Med, Dept Physiol, Isehara, Kanagawa 2991193, Japan
来源：
CURRENT OPINION IN MOLECULAR THERAPEUTICS | 2002年 / 4卷 / 04期
关键词：
EPCs; postnatal vasculogenesis; therapeutic vasculogenesis; cell/gene therapy;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
It has recently been demonstrated that postnatal neovascularization is not restricted to angiogenesis, but also includes vasculogenesis. During adult vasculogenesis, bone marrow (BM)-derived endothelial progenitor cells (EPCs) are recruited to the systemic circulation in response to certain cytokines and/or tissue ischemia, and incorporate into sites of neovascularization. EPCs have also been investigated as therapeutic agents in a 'supply-side' approach to promoting neovascularization under pathological conditions. This review highlights the discovery of BM-derived EPCs and their therapeutic potential for vascular regeneration.
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收藏
页码：395 / 402
页数：8
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