Is oxidative stress associated with disease severity, pulmonary function and metabolic syndrome in chronic obstructive pulmonary disease?

Objective: To investigate associations between oxidant/antioxidant biomarkers with the disease severity, pulmonary function and diagnosis of metabolic syndrome (MetS) in patients with COPD. Methods: Seventy-four subjects were included, 39 with COPD (age 69 +/- 7 years; female 41%) and 35 for control group (age 69 +/- 7 years; female 43%). They were diagnosed with MetS and allocated in one of 4 subgroups: COPD and control, with and without MetS, respectively. Advanced oxidation protein products (AOPP), paraoxonase-1, catalase activity, sulfhydryl group and total lipid hydroperoxide were assayed. Pulmonary function was performed with a plethysmograph. Results: COPD severity (GOLD >= 3) and pulmonary function were associated with sulfhydryl group and AOPP (P <= .03 for all). The prevalence of MetS was associated with AOPP in COPD (P=.04). Individuals with COPD and MetS showed higher AOPP compared to COPD without MetS (P<.0001). Conclusion: COPD severity, worse pulmonary function and presence of metabolic syndrome are associated with oxidative stress in individuals with COPD. (C) 2019 Elsevier Espana, S.L.U. and Sociedad Espanola de Medicina Interna (SEMI). Alt rights reserved.