Insights into the role of the intestinal microbiota in colon cancer

被引:27
|
作者
Oke, Sofia [1 ]
Martin, Alberto [1 ]
机构
[1] Univ Toronto, Dept Immunol, 1 Kings Coll Cir,MSB 7302, Toronto, ON M5S 1A1, Canada
关键词
colon cancer; inflammation; microbiota; organoids; COLORECTAL-CANCER; GUT MICROBIOTA; MOUSE MODEL; ORGANOIDS; TUMORIGENESIS; INFLAMMATION; CELLS; RISK; CONSEQUENCES; METABOLISM;
D O I
10.1177/1756283X17694832
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The intestinal microbiota consists of a dynamic organization of bacteria, viruses, archaea, and fungal species essential for maintaining gut homeostasis and protecting the host against pathogenic invasion. When dysregulated, the intestinal microbiota can contribute to colorectal cancer development. Though the microbiota is multifaceted in its ability to induce colorectal cancer, this review will focus on the capability of the microbiota to induce colorectal cancer through the modulation of immune function and the production of microbial-derived metabolites. We will also explore an experimental technique that is revolutionizing intestinal research. By elucidating the interactions of microbial species with epithelial tissue, and allowing for drug screening of patients with colorectal cancers, organoid development is a novel culturing technique that is innovating intestinal research. As a cancer that remains one of the leading causes of cancer-related deaths worldwide, it is imperative that scientific findings are translated into the creation of effective therapeutics to treat colorectal cancer.
引用
收藏
页码:417 / 428
页数:12
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