Practical synthesis of a 3, 4, 4a, 5, 8, 8a-hexahydro-2H-isoquinoline-1, 6-dione ring system by the diels-alder reaction of an optically active dienophile, a 5, 6-dihydro-1H-pyridin-2-one derivative, with siloxydiene

被引：0

作者：

Nakagawa, M ^{[1
]}

Uchida, H ^{[1
]}

Ono, K ^{[1
]}

Kimura, Y ^{[1
]}

Yamabe, M ^{[1
]}

Watanabe, T ^{[1
]}

Tsuji, R ^{[1
]}

Akiba, M ^{[1
]}

Terada, Y ^{[1
]}

Nagaki, D ^{[1
]}

Ban, S ^{[1
]}

Miyashita, N ^{[1
]}

Kano, T ^{[1
]}

Theeraladanon, C ^{[1
]}

Hatakeyama, K ^{[1
]}

Arisawa, M ^{[1
]}

Nishida, A ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

来源：

HETEROCYCLES | 2003年 / 59卷 / 02期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for preparing chiral 3-substituted-5, 6-dihydro-1H-pyridin-2-one (1) in large scale, based on a modification of our previous method, is described. The large scale Diels-Alder reaction of I with siloxydiene (2) to synthesize hexahydroisoquinoline-1, 6-dione, which is a key intermediate for the synthesis of manzamine alkaloids, was also studied.

引用

页码：721 / 733

页数：13

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