A novel c-Met/EGFR bispecific targeting antibody drug conjugate for NSCLC

被引：1
|
作者：
Chen, Gang [1 ]
Li, Lingna [1 ]
Muyot, Pia [1 ]
Gros, Edwige [1 ]
Zhang, Yanliang [1 ]
Sun, Yingqing [1 ]
Zhang, Hong [1 ]
Fu, Yanwen [1 ]
Lee, Alice [1 ]
Cao, Jian [1 ]
Kaufmann, Gunnar [1 ]
Miao, Zhenwei [1 ]
机构：
[1] Concortis Biosyst, San Diego, CA USA
来源：
CANCER RESEARCH | 2015年 / 75卷
关键词：
D O I：
10.1158/1538-7445.AM2015-LB-002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
LB-002
引用
收藏
页数：3
相关论文
共 50 条
  • [1] A novel c-Met targeting antibody drug conjugate for NSCLC
    Li, Lingna
    Fells, Cathrine
    Guo, Julia
    Muyot, Pia
    Gros, Edwige
    Zhang, Yanliang
    Sun, Yingqing
    Zhang, Hong
    Fu, Yanwen
    Zhu, Tong
    Cao, Jian
    Kaufmann, Gunnar
    Chen, Gang
    Miao, Zhenwei
    CANCER RESEARCH, 2016, 76
  • [2] Preclinical evaluation of MCLA-129: A bispecific antibody targeting c-MET and EGFR
    Geuijen, Cecile
    di Matteo, Mario
    Gallenne, Tristan
    Cafarello, Sarah Trusso
    Nijhuis, Roy
    Visser, Therese
    Bartelink, Willem
    Bartelink-Clements, Carina
    Eppink, Berina
    Klooster, Rinse
    Dekruif, John
    Mazzone, Massimiliano
    Throsby, Mark
    MOLECULAR CANCER THERAPEUTICS, 2019, 18 (12)
  • [3] BYON3521, a novel effective and safe c-Met targeting antibody-drug conjugate.
    Groothuis, Patrick
    Jacobs, Danielle
    Hermens, Inge
    Damming, Desiree
    Mattaar, Ellen
    Rouwette, Myrthe
    van der Vleuten, Monique
    Sesink, Aloys
    Dijcks, Fred
    Coumans, Ruud
    Blomenrohr, Marion
    Ubink, Ruud
    van der Lee, Miranda
    Dokter, Wim H. A.
    CANCER RESEARCH, 2021, 81 (13)
  • [4] 177Lu-labeled bispecific antibodies targeting EGFR and c-MET as radiotheranostics in murine NSCLC tumor model
    Li, Cuicui
    Li, Bingyu
    Zhao, Tianzhi
    Wei, Zhenni
    Chen, Xiaoyuan
    Zhang, Jingjing
    JOURNAL OF NUCLEAR MEDICINE, 2024, 65
  • [5] Cross-arm binding efficiency of an EGFR x c-Met bispecific antibody
    Zheng, Songmao
    Moores, Sheri
    Jarantow, Stephen
    Pardinas, Jose
    Chiu, Mark
    Zhou, Honghui
    Wang, Weirong
    MABS, 2016, 8 (03) : 551 - 561
  • [6] CROSS-ARM BINDING EFFICIENCY OF AN EGFR X C-MET BISPECIFIC ANTIBODY
    Zheng, S.
    Moores, S.
    Jarantow, S.
    Pardinas, J.
    Chiu, M.
    Zhou, H.
    Wang, W.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2017, 101 (S1) : S14 - S14
  • [7] BCG022: A novel bispecific antibody-drug conjugate targeting HER3 and MET
    Li, Zhuolin
    Shang, Chengzhang
    Guan, Xuewa
    Han, Zhenyan
    An, Gao
    Zhang, Ellen
    Lin, Qingcong
    Yang, Yi
    CANCER RESEARCH, 2023, 83 (08)
  • [8] A Novel c-MET-Targeting Antibody-Drug Conjugate for Pancreatic Cancer
    Jin, Yangbing
    Zhang, Zehui
    Zou, Siyi
    Li, Fanlu
    Chen, Hao
    Peng, Chenghong
    Deng, Xiaxing
    Wen, Chenlei
    Shen, Baiyong
    Zhan, Qian
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [9] Generation and Characterization of a Bispecific Antibody Targeting Both PD-1 and c-MET
    Wu, Yi
    Yu, Min
    Sun, Zujun
    Hou, Weihua
    Wang, Yuxiong
    Yuan, Qingyun
    Mo, Wei
    PROTEIN AND PEPTIDE LETTERS, 2017, 24 (12): : 1105 - 1112
  • [10] Mechanisms of EGFR and c-Met inhibitor resistance in NSCLC
    Fong, Jason T.
    Puri, Neelu
    CANCER RESEARCH, 2011, 71
12345