Melatonin lowers edema after spinal cord injury

被引：20
|
作者：
Li, Cheng [1 ]
Chen, Xiao [1 ]
Qiaol, Suchi [1 ]
Liu, Xinwei [2 ]
Liu, Chang [1 ]
Zhu, Degang [1 ]
Su, Jiacan [1 ]
Wang, Zhiwei [1 ]
机构：
[1] Second Mil Med Univ, Changhai Hosp, Dept Orthoped Surg, Shanghai 200433, Peoples R China
[2] Gen Hosp Shenyang Mil Area Command Chinese PLA, Lab Severe & Warrelated Trauma Ctr, Shenyang, Liaoning Provin, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2014年 / 9卷 / 24期
基金：
中国博士后科学基金;
关键词：
nerve regeneration; spinal cord injury; melatonin; edema; aquaporin; glial fibrillary acidic protein; immunohistochemistry; western blot assay; neural regeneration; AQUAPORIN-4; EXPRESSION; TIRILAZAD MESYLATE; SECONDARY INJURY; ISCHEMIC-INJURY; NEURONAL DEATH; WATER CHANNELS; METHYLPREDNISOLONE; NALOXONE; RECOVERY;
D O I：
10.4103/1673-5374.147954
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Melatonin has been shown to diminish edema in rats. Melatonin can be used to treat spinal cord injury. This study presumed that melatonin could relieve spinal cord edema and examined how it might act. Our experiments found that melatonin (100 mg/kg, i.p.) could reduce the water content of the spinal cord, and suppress the expression of aquaporin-4 and glial fibrillary acidic protein after spinal cord injury. This suggests that the mechanism by which melatonin alleviates the damage to the spinal cord by edema might be related to the expression of aquaporin-4 and glial fibrillary acidic protein.
引用
收藏
页码：2205 / 2210
页数：6
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