Alkoxylation Followed by Iodination of Oxindole with Alcohols Mediated by Hypervalent Iodine Reagent in the Presence of Iodine

被引：16

作者：

Kotagiri, Rajendraprasad ^{[1
,2
]}

Adepu, Ramesh ^{[3
]}

机构：

[1] Jinan Univ, Coll Pharm, 601 Huangpu Ave West, Guangzhou 510632, Guangdong, Peoples R China

[2] CSIR, Indian Inst Chem Technol, Inorgan & Phys Chem Div, Uppal Rd, Hyderabad 500007, Telangana, India

[3] CSIR, Indian Inst Chem Technol, Organ & Biomol Chem Div, Hyderabad 500007, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 2018卷 / 33期

关键词：

Iodine-mediated reactions; Hypevalent Iodine; Alcohols; Oxindoles; Metal-free; Iodine; SIMPLE INDOLE ALKALOIDS; TRIMETHYLSILYL ENOL ETHERS; ARYL FORMAMIDES; GENERAL-ROUTE; OXIDATION; ALKENES; BONDS; MILD;

D O I：

10.1002/ejoc.201800723

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxidative coupling of oxindole with alcohols followed by in situ iodination by using a PhI(OCOCF3)(2)/I-2 system afforded 5-iodo-3-monoalkoxy and 5-iodo-3,3-di alkoxyoxindole in moderate to good yields. This method provides a new and transition metal-free synthesis of iodoalkoxy-substituted oxindoles in one pot from readily available oxindole under mild conditions.

引用

页码：4556 / 4564

页数：9

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