MACROCYCLIC LACTONIZATION OF 3R,7-DIMETHYL-6S-HYDROXYOCTANOIC ACID

被引：1

作者：

Yakovleva, M. P. ^{[1
]}

Mingaleeva, G. R. ^{[1
]}

Denisova, K. S. ^{[1
]}

Kravchenko, A. A. ^{[1
]}

Vyrypaev, E. M. ^{[1
]}

Ishmuratov, G. Yu ^{[1
]}

机构：

[1] Russian Acad Sci, Ufa Inst Chem, 71 Prosp Oktyabrya, Ufa 450054, Russia

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2018年 / 54卷 / 04期

关键词：

1-menthol; 3R; 7-dimethyl-6S-hydroxyoctanoic acid; dicarboxylic acid dichlorides; pyridine; N; N-dimethylaminopyridine;

D O I：

10.1007/s10600-018-2446-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A mixture of cyclic lactones [7- (mentholactone), 14-, 21-, 28-, and 35-membered polylactones] instead of the expected [2 + 1]-condensation products was obtained from the reaction of 3R, 7-dimethyl-6S-hydroxyoctanoic acid, which is accessible from l-menthol, and glutaric, adipic, and bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid dichlorides in Py in the presence of N,N-dimethylaminopyridine. The structures were confirmed using PMR, C-13 NMR, and mass spectra.

引用

页码：684 / 687

页数：4

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