Solute-solvent and solvent-solvent interactions and preferential solvation of hesperidin in aqueous cosolvent mixtures of ethanol, isopropanol, propylene glycol and n-propanol

Solute-solvent and solvent-solvent interactions were investigated from the available solubility data by using the linear solvation energy relationships concept. The variation of hesperidin solubility depended upon hydrogen bond basicity for ethanol (1) + water (2), hydrogen bond basicity and dipolarity/polarizability for isopropanol (1) + water (2), hydrogen bond basicity, dipolarity/polarizability and cavity term for n-propanol (1) + water (2), and dipolarity/polarizability and cavity term of PG (1) + water (2). Furthermore, the preferential solvation parameter (delta chi(1,3)) of hesperidin in four cosolvent mixtures of ethanol (1) + water (2), isopropanol (1) + water (2), propylene glycol (PG) (1) + water (2) and n-propanol (1) + water (2) was deduced from the solubility data with the inverse Kirkwood-Buff integrals method. In water-rich compositions for the four aqueous cosolvent mixtures, the value of delta chi(1,3)was negative at temperatures ranging from 293.15 K to 313.15 K, which indicated that the hesperidin was preferentially solvated by water. In intermediate composition and cosolvent-rich composition, hesperidin was preferentially solvated by the cosolvent (ethanol, isopropanol or n-propanol). (C) 2018 Elsevier B.V. All rights reserved.