Hydrophobic Triaryl-Substituted β-Lactams as Activity-Based Probes for Profiling Eukaryotic Enzymes and Host-Pathogen Interactions

被引：11

作者：

Nasheri, Neda ^{[1
,2
]}

McKay, Craig S. ^{[1
,3
]}

Fulton, Kelly ^{[1
]}

Twine, Susan ^{[1
]}

Powdrill, Megan H. ^{[1
,3
]}

Sherratt, Allison R. ^{[1
]}

Pezacki, John Paul ^{[1
,2
,3
]}

机构：

[1] Natl Res Council Canada, Div Life Sci, Ottawa, ON K1A 0R6, Canada

[2] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada

[3] Univ Ottawa, Dept Chem, Ottawa, ON K1N 6N5, Canada

来源：

CHEMBIOCHEM | 2014年 / 15卷 / 15期

关键词：

activity-based protein profiling; beta-lactams; eukaryote; hepatitis C virus; mass spectrometry; HEPATITIS-C-VIRUS; HEPATOCELLULAR-CARCINOMA; PROTEOMIC ANALYSIS; CELL-CYCLE; PROTEIN; REPLICATION; RESISTANCE; ANTIBIOTICS; MODULATION; MECHANISMS;

D O I：

10.1002/cbic.201402097

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ABPP with β-lactams: We identified the eukaryotic targets of β-lactam-containing compounds by activity-based protein profiling. Using this method, we demonstrated that β-lactam-based activity probes can be applied to identify differentially active enzymes in different cell lines and during hepatitis C virus replication. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2195 / 2200

页数：6

共 6 条

[1] Activity-Based Protein Profiling at the Host-Pathogen Interface
Kovalyova, Yekaterina
Hatzios, Stavroula K.
ACTIVITY-BASED PROTEIN PROFILING, 2019, 420 : 73 - 91
[2] Activity-based protein profiling of host-virus interactions
Blais, David R.
Nasheri, Neda
McKay, Craig S.
Legault, Marc C. B.
Pezacki, John Paul
TRENDS IN BIOTECHNOLOGY, 2012, 30 (02) : 89 - 99
[3] Recent advances in activity-based probes (ABPs) and affinity-based probes (AfBPs) for profiling of enzymes
Fang, Haixiao
Peng, Bo
Ong, Sing Yee
Wu, Qiong
Li, Lin
Yao, Shao Q.
CHEMICAL SCIENCE, 2021, 12 (24) : 8288 - 8310
[4] Dynamic and Functional Profiling of Xylan-Degrading Enzymes in Aspergillus Secretomes Using Activity-Based Probes
Schroder, Sybrin P.
de Boer, Casper
McGregor, Nicholas G. S.
Rowland, Rhianna J.
Moroz, Olga
Blagova, Elena
Reijngoud, Jos
Arentshorst, Mark
Osborn, David
Morant, Marc D.
Abbate, Eric
Stringer, Mary A.
Krogh, Kristian B. R. M.
Raich, Lluis
Rovira, Carme
Berrin, Jean-Guy
van Wezel, Gilles P.
Ram, Arthur F. J.
Florea, Bogdan, I
van der Marel, Gijsbert A.
Codee, Jeroen D. C.
Wilson, Keith S.
Wu, Liang
Davies, Gideon J.
Overkleeft, Herman S.
ACS CENTRAL SCIENCE, 2019, 5 (06) : 1067 - 1078
[5] Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions
Ismail, Hanafy M.
O'Neill, Paul M.
Hong, David W.
Finn, Robert D.
Henderson, Colin J.
Wright, Aaron T.
Cravatt, Benjamin F.
Hemingway, Janet
Paine, Mark J. I.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (49) : 19766 - 19771
[6] Activity-based proteome profiling of hepatitis C virus replication: Newly discovered roles of host cell hydrolase enzymes in the viral life cycle
Pezacki, John P.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241

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