The Regulation of Bone Metabolism and Disorders by Wnt Signaling

被引：268

作者：

Maeda, Kazuhiro ^{[1
]}

Kobayashi, Yasuhiro ^{[2
]}

Koide, Masanori ^{[2
]}

Uehara, Shunsuke ^{[3
]}

Okamoto, Masanori ^{[4
]}

Ishihara, Akihiro ^{[5
]}

Kayama, Tomohiro ^{[1
]}

Saito, Mitsuru ^{[1
]}

Marumo, Keishi ^{[1
]}

机构：

[1] Jikei Univ, Dept Orthopaed Surg, Sch Med, Minato Ku, 3-25-8 Nishi Shimbashi, Tokyo 1058461, Japan

[2] Matsumoto Dent Univ, Inst Oral Sci, 1780 Gohara Hiro Oka, Shiojiri, Nagano 3990781, Japan

[3] Matsumoto Dent Univ, Dept Biochem, 1780 Gohara Hiro Oka, Shiojiri, Nagano 3990781, Japan

[4] Shinshu Univ, Dept Orthopaed Surg, Sch Med, 3-1-1 Asahi, Matsumoto, Nagano 3908621, Japan

[5] Hiruma Dent Clin, Katsushika Ku, 5-34-16-4F Kameari, Tokyo 1250061, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 22期

关键词：

osteoclast; osteoblast; osteocyte; Wnt; sclerostin; osteoporosis; romosozumab; osteoarthritis; rheumatoid arthritis; skeletal-related events; MESENCHYMAL STEM-CELLS; MAMMARY ONCOGENE INT-1; SCLEROSTIN EXPRESSION; RHEUMATOID-ARTHRITIS; CORTICAL-BONE; POSTMENOPAUSAL WOMEN; INHIBITORY FACTOR-1; OSTEOCYTE CONTROL; DNA METHYLATION; MINERAL DENSITY;

D O I：

10.3390/ijms20225525

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Wnt, a secreted glycoprotein, has an approximate molecular weight of 40 kDa, and it is a cytokine involved in various biological phenomena including ontogeny, morphogenesis, carcinogenesis, and maintenance of stem cells. The Wnt signaling pathway can be classified into two main pathways: canonical and non-canonical. Of these, the canonical Wnt signaling pathway promotes osteogenesis. Sclerostin produced by osteocytes is an inhibitor of this pathway, thereby inhibiting osteogenesis. Recently, osteoporosis treatment using an anti-sclerostin therapy has been introduced. In this review, the basics of Wnt signaling, its role in bone metabolism and its involvement in skeletal disorders have been covered. Furthermore, the clinical significance and future scopes of Wnt signaling in osteoporosis, osteoarthritis, rheumatoid arthritis and neoplasia are discussed.

引用

页数：37

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