On the employment of λ carrageenan in a matrix system.: III.: Optimization of a λ carrageenan-HPMC hydrophilic matrix

被引：50
|
作者：
Bonferoni, MC
Rossi, S
Ferrari, F
Bertoni, M
Bolhuis, GK
Caramella, C
机构：
[1] Univ Pavia, Dept Pharmaceut Chem, I-27100 Pavia, Italy
[2] Univ Groningen, Dept Pharmaceut Technol & Biopharm, Groningen, Netherlands
来源：
JOURNAL OF CONTROLLED RELEASE | 1998年 / 51卷 / 2-3期
关键词：
lambda carrageenan; hydrophilic matrices; optimization; hydroxypropylmethylcellulose; chlorpheniramine maleate;
D O I：
10.1016/S0168-3659(97)00175-2
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The lambda carrageenan/HPMC ratio in matrix tablets has been optimized in order to obtain pH-independent release profiles of chlorpheniramine maleate, a freely soluble drug. Release profiles in acidic (pH 1.2) and neutral (pH 6.8) media were fitted according to the Weibull and the power law models. Model independent parameters (t(50%) and the percentage of drug released after 2 h) were also calculated. The Weibull parameters were found suitable to describe the dependence of the release profiles on matrix composition. Preparation and testing of the optimized formulation showed linear and pH-independent release profiles lasting about 24 h, in good accordance with the values predicted by the optimization procedure. (C) 1998 Elsevier Science B.V.
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页码：231 / 239
页数：9
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