The Crystal Structure of ELIC in Complex with Chlorpromazine Unexpectedly Unveils an Allosteric Binding Site in the Ligand-Binding Domain

被引:0
|
作者
Nys, Mieke [1 ]
Farinha, Ana [1 ]
Wijckmans, Eveline [1 ]
Brams, Marijke [1 ]
Yoluk, Ozge [2 ]
Andersson, Magnus [2 ]
Lindahl, Erik [2 ]
Ulens, Chris [1 ]
机构
[1] Katholieke Univ Leuven, Lab Struct Neurobiol, Leuven, Belgium
[2] KTH Royal Inst Technol, Theoret & Computat Biophys, Stockholm, Sweden
关键词
D O I
10.1016/j.bpj.2015.11.2448
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
2252-Pos
引用
收藏
页码:457A / 457A
页数:1
相关论文
共 50 条
  • [1] Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine
    Nys, Mieke
    Wijckmans, Eveline
    Farinha, Ana
    Yoluk, Ozge
    Andersson, Magnus
    Brams, Marijke
    Spurny, Radovan
    Peigneur, Steve
    Tytgat, Jan
    Lindahl, Erik
    Ulens, Chris
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (43) : E6696 - E6703
  • [2] Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor
    Christian Wiesmann
    Mark H. Ultsch
    Steven H. Bass
    Abraham M. de Vos
    [J]. Nature, 1999, 401 : 184 - 188
  • [3] THE ANTAGONISTIC CRYSTAL STRUCTURE OF THE GLUCOCORTICOID RECEPTOR, LIGAND-BINDING DOMAIN
    Kauppi, B.
    Jakob, C.
    Farnegardh, M.
    Ahola, H.
    Alarcon, M.
    Calles, K.
    Engstrom, O.
    Harlan, J.
    Ramkvist, A. -K.
    Thorell, S.
    Young, J.
    Ohman, L.
    Greer, J.
    Gustafsson, J. -A.
    Carlstedt-Duke, J.
    Carlquist, M.
    [J]. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2002, 58 : C201 - C201
  • [4] Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor
    Wiesmann, C
    Ultsch, MH
    Bass, SH
    de Vos, AM
    [J]. NATURE, 1999, 401 (6749) : 184 - 188
  • [5] Exploring the binding site structure of the PPARγ ligand-binding domain by computational solvent mapping
    Sheu, SH
    Kaya, T
    Waxman, DJ
    Vajda, S
    [J]. BIOCHEMISTRY, 2005, 44 (04) : 1193 - 1209
  • [6] Crystal structure of afadin PDZ domain-nectin-3 complex shows the structural plasticity of the ligand-binding site
    Fujiwara, Yoshie
    Goda, Natsuko
    Tamashiro, Tomonari
    Narita, Hirotaka
    Satomura, Kaori
    Tenno, Takeshi
    Nakagawa, Atsushi
    Oda, Masayuki
    Suzuki, Mamoru
    Sakisaka, Toshiaki
    Takai, Yoshimi
    Hiroaki, Hidekazu
    [J]. PROTEIN SCIENCE, 2015, 24 (03) : 376 - 385
  • [7] Crystal structure of the human liver X receptor β ligand-binding domain in complex with a synthetic agonist
    Hoerer, S
    Schmid, A
    Heckel, A
    Budzinski, RM
    Nar, H
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 2003, 334 (05) : 853 - 861
  • [8] Allosteric Conversation in the Androgen Receptor Ligand-Binding Domain Surfaces
    Grosdidier, Solene
    Carbo, Laia R.
    Buzon, Victor
    Brooke, Greg
    Nguyen, Phuong
    Baxter, John D.
    Bevan, Charlotte
    Webb, Paul
    Estebanez-Perpina, Eva
    Fernandez-Recio, Juan
    [J]. MOLECULAR ENDOCRINOLOGY, 2012, 26 (07) : 1078 - 1090
  • [9] The 2.0 Å crystal structure of the ERα ligand-binding domain complexed with lasofoxifene
    Vajdos, Felix F.
    Hoth, Lise R.
    Geoghegan, Kieran F.
    Simons, Samuel P.
    Lemotte, Peter K.
    Danley, Dennis E.
    Ammirati, Mark J.
    Pandit, Jayvardhan
    [J]. PROTEIN SCIENCE, 2007, 16 (05) : 897 - 905
  • [10] Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
    Brejc, K
    van Dijk, WJ
    Klaassen, RV
    Schuurmans, M
    van der Oost, J
    Smit, AB
    Sixma, TK
    [J]. NATURE, 2001, 411 (6835) : 269 - 276