Nanoparticle targeting of anti-cancer drugs that alter intracellular signaling or influence the tumor microenvironment

被引：185
|
作者：
Kanapathipillai, Mathumai [1 ]
Brock, Amy [2 ]
Ingber, Donald E. [1 ,3 ,4 ,5 ]
机构：
[1] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA
[2] Univ Texas Austin, Inst Cellular & Mol Biol, Dept Biomed Engn, Austin, TX 78712 USA
[3] Boston Childrens Hosp, Vasc Biol Program, Boston, MA USA
[4] Harvard Univ, Sch Med, Boston, MA 02115 USA
[5] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2014年 / 79-80卷
关键词：
Nanoparticle; Tumor; Nanotherapeutics; Delivery; Microenvironment; Drug; MESOPOROUS SILICA NANOPARTICLES; BREAST-CANCER CELLS; DENDRITIC CELLS; LYSYL OXIDASE; EXTRACELLULAR-MATRIX; GOLD NANOPARTICLES; POLYMERIC NANOPARTICLES; MAGNETIC NANOPARTICLES; MULTIDRUG-RESISTANCE; LIPID NANOPARTICLES;
D O I：
10.1016/j.addr.2014.05.005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nanoparticle-based therapeutics are poised to become a leading delivery strategy for cancer treatment because they potentially offer higher selectivity, reduced toxicity, longer clearance times, and increased efficacy compared to conventional systemic therapeutic approaches. This article reviews existing nanoparticle technologies and methods that are used to target drugs to treat cancer by altering signal transduction or modulating the tumor microenvironment We also consider the implications of recent advances in the nanotherapeutics field for the future of cancer therapy. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：107 / 118
页数：12
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