Two endoscopic submucosal dissection procedures for stripping huge segment of the gastric mucosa to treat early gastric signet ring cell carcinoma

Aim: To introduce the method of stripping of early gastric signet ring cell carcinioma by two ESD procedures. Methods: A lesion of early gastric signet ring cell carcinoma in an elderly was removed by two consecutive ESD procedures. The pathology was analyzed and the patient was followed-up. Results: The lesion removed by first ESD procedure, which was 10cm in diameter, has tumor tissue on its edge, and the second lesion which was 5cm in diameter had an edge without tumor. There was no metastasis or recurrence during 24-month follow-up. Conclusion: We first described the method using two consecutive ESD procedures in man with gastric signet ring cell carcinoma, and the procedure was proved to be safe and efficient.