Friedelane triterpenoids from Maytenus macrocarpa

被引：30
|
作者：
Chávez, H [1 ]
Estévez-Braun, A [1 ]
Ravelo, AG [1 ]
González, AG [1 ]
机构：
[1] Univ La Laguna, Inst Bioorgan Antonio Gonzalez, E-38206 Tenerife, Canary Island, Spain
来源：
JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 01期
关键词：
D O I：
10.1021/np970232k
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A set of friedelane triterpenoids has been isolated from the stem bark exudates of Maytenus macrocarpa. It includes a new friedelan triterpene (1), together with the known compounds friedelin, 3-oxo-29-hydraxyfriedelane, 3-oxofriedelan-25-al, and canophyllol. The structures of these compounds were elucidated by spectroscopic and chemical evidence. Complete H-1 and C-13 assignments were achieved by 2D NMR spectroscopy. The new compound showed weak activity against aldose reductase. It did not display antitumor activity against P-388 lymphoid neoplasm, A-549 human lung carcinoma, HT-29 human colon carcinoma, or MEL-28 human melanoma cell lines.
引用
收藏
页码：82 / 85
页数：4
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