The Sense of Smell Impacts Metabolic Health and Obesity

被引：123

作者：

Riera, Celine E. ^{[1
,2
,3
,4
]}

Tsaousidou, Eva ^{[5
,6
,7
,8
,9
,10
]}

Halloran, Jonathan ^{[1
,2
,3
]}

Follett, Patricia ^{[11
]}

Hahn, Oliver ^{[7
,8
]}

Pereira, Mafalda M. A. ^{[5
,6
]}

Ruud, Linda Engstroem ^{[5
,6
]}

Alber, Jens ^{[5
,6
]}

Tharp, Kevin ^{[12
]}

Anderson, Courtney M. ^{[12
]}

Broenneke, Hella ^{[5
,6
]}

Hampel, Brigitte ^{[5
,6
]}

de Magalhaes Filho, Carlos Daniel ^{[11
]}

Stahl, Andreas ^{[12
]}

Bruening, Jens C. ^{[5
,6
,7
,8
]}

Dillin, Andrew ^{[1
,2
,3
]}

机构：

[1] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Paul F Glenn Ctr Aging Res, Berkeley, CA 94720 USA

[4] Cedars Sinai Med Ctr, Diabet & Obes Res Inst, 8700 Beverly Blvd, Los Angeles, CA 90048 USA

[5] Max Planck Inst Metab Res, Dept Neuronal Control Metab, Gleueler Str 50, Cologne, Germany

[6] Univ Hosp Cologne, Ctr Endocrinol Diabet & Prevent Med CEDP, Kerpener Str 26, Cologne, Germany

[7] Max Planck Inst Biol Ageing, Cologne, Germany

[8] Excellence Cluster Cellular Stress Responses Agin, Cologne, Germany

[9] Harvard TH Chan Sch Publ Hlth, Dept Genet, Boston, MA USA

[10] Harvard TH Chan Sch Publ Hlth, Complex Dis & Sabri Ulker Ctr, Boston, MA USA

[11] Salk Inst Biol Studies, 10010 North Torrey Pines Rd, La Jolla, CA 92037 USA

[12] Univ Calif Berkeley, Nutr Sci & Toxicol, Berkeley, CA 94720 USA

来源：

CELL METABOLISM | 2017年 / 26卷 / 01期

关键词：

WHITE ADIPOSE-TISSUE; LEPTIN RECEPTOR; TARGETED DISRUPTION; ENERGY HOMEOSTASIS; EXPRESSING NEURONS; INSULIN-RECEPTORS; SKELETAL-MUSCLE; MICE LACKING; IGF-I; RAT;

D O I：

10.1016/j.cmet.2017.06.015

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Olfactory inputs help coordinate food appreciation and selection, but their role in systemic physiology and energy balance is poorly understood. Here we demonstrate that mice upon conditional ablation of mature olfactory sensory neurons (OSNs) are resistant to diet-induced obesity accompanied by increased thermogenesis in brown and inguinal fat depots. Acute loss of smell perception after obesity onset not only abrogated further weight gain but also improved fat mass and insulin resistance. Reduced olfactory input stimulates sympathetic nerve activity, resulting in activation of beta-adrenergic receptors on white and brown adipocytes to promote lipolysis. Conversely, conditional ablation of the IGF1 receptor in OSNs enhances olfactory performance in mice and leads to increased adiposity and insulin resistance. These findings unravel a new bidirectional function for the olfactory system in controlling energy homeostasis in response to sensory and hormonal signals.

引用

页码：198 / +

页数：19

共 50 条

[1] The sense of smell impacts metabolic health and obesity
Riera, Celine E.
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