APC, signal transduction and genetic instability in colorectal cancer

被引：727
|
作者：
Fodde, R
Smits, R
Clevers, H
机构：
[1] Leiden Univ, Med Ctr, Dept Human & Clin Genet, NL-2300 RA Leiden, Netherlands
[2] Leiden Univ, Med Ctr, Ctr Biomed Genet, NL-2300 RA Leiden, Netherlands
[3] Univ Utrecht, Med Ctr, Dept Immunol, NL-3508 GA Utrecht, Netherlands
[4] Univ Utrecht, Med Ctr, Ctr Biomed Genet, NL-3508 GA Utrecht, Netherlands
来源：
NATURE REVIEWS CANCER | 2001年 / 1卷 / 01期
关键词：
D O I：
10.1038/35094067
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colorectal cancer arises through a gradual series of histological changes, each of which is accompanied by a specific genetic alteration. In general, an intestinal cell needs to comply with two essential requirements to develop into a cancer: it must acquire selective advantage to allow for the initial clonal expansion, and genetic instability to allow for multiple hits in other genes that are responsible for tumour progression and malignant transformation. Inactivation of APC the gene responsible for most cases of colorectal cancer - might fulfil both requirements.
引用
收藏
页码：55 / 67
页数：13
相关论文
共 50 条
  • [1] APC, Signal transduction and genetic instability in colorectal cancer
    Riccardo Fodde
    Ron Smits
    Hans Clevers
    Nature Reviews Cancer, 2001, 1 : 55 - 67
  • [2] Signal transduction and genetic instability in colorectal cancer: it takes two to tango
    Fodde, R
    EUROCANCER 2002, 2002, : 77 - 77
  • [3] The molecular genetic basis of colorectal cancer: It takes two (signal transduction and genetic instability) to tango
    Fodde, R
    TOXICOLOGY, 2001, 168 (01) : 30 - 30
  • [4] Genetic instability in colorectal cancer
    Thomas, HJW
    GUT, 1998, 43 (04) : 450 - 450
  • [5] Signal transduction pathways in colorectal cancer (CRC)
    Johnston, P.
    Tabernero, J.
    Ramos, F. J.
    Macarulla, T.
    Capdevila, J.
    Peralta, S.
    Elez, E.
    EJC SUPPLEMENTS, 2007, 5 (04): : 26 - 26
  • [6] Signal transduction, cancer classification and genetic variation
    Lander E.S.
    Nature Genetics, 1999, 23 (Suppl 3) : 29 - 29
  • [7] Genetic abnormalities and microsatellite instability in colorectal cancer
    Iniesta, P
    de Juan, C
    Caldes, T
    Vega, FJ
    Massa, MJ
    Cerdan, FJ
    Lopez, JA
    Fernandez, C
    Sanchez, A
    Torres, AJ
    Balibrea, JL
    Benito, M
    CANCER DETECTION AND PREVENTION, 1998, 22 (05): : 383 - 395
  • [8] Colorectal cancer without high microsatellite instability and chromosomal instability - an alternative genetic pathway to human colorectal cancer
    Tang, RP
    Changchien, CR
    Wu, MC
    Fan, CW
    Liu, KW
    Chen, JS
    Chien, HT
    Hsieh, LL
    CARCINOGENESIS, 2004, 25 (05) : 841 - 846
  • [9] DNA methylation and genetic instability in colorectal cancer cells
    Lengauer, C
    Kinzler, KW
    Vogelstein, B
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (06) : 2545 - 2550
  • [10] Dynamics of genetic instability in sporadic and familial colorectal cancer
    Komarova, NL
    Lengauer, C
    Vogelstein, B
    Nowak, MA
    CANCER BIOLOGY & THERAPY, 2002, 1 (06) : 685 - 692
12345