Comparative anatomy and morphology of the knee in translational models for articular cartilage disorders. Part II: Small animals

被引：14
|
作者：
Olah, Tamas [1 ]
Michaelis, Jana Christin [1 ]
Cai, Xiaoyu [1 ]
Cucchiarini, Magali [1 ]
Madry, Henning [1 ,2 ]
机构：
[1] Saarland Univ, Ctr Expt Orthopaed, Homburg, Germany
[2] Saarland Univ, Dept Orthopaed Surg, Med Ctr, Kirrberger Str,Bldg 37, D-66421 Homburg, Germany
来源：
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER | 2021年 / 234卷
关键词：
Small animal model; knee; human; osteochondral unit; articular cartilage; subchondral bone; range of motion; SUBCHONDRAL BONE TISSUES; GUINEA-PIG MODEL; CRUCIATE LIGAMENT TRANSECTION; MECHANICAL-PROPERTIES; RABBIT KNEE; SPONTANEOUS OSTEOARTHRITIS; 3-DIMENSIONAL MICROARCHITECTURE; OSTEOCHONDRAL DEFECTS; MENISCAL OSSIFICATION; TIBIAL PLATEAU;
D O I：
10.1016/j.aanat.2020.151630
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Background: Small animal models are critical to model the complex disease mechanisms affecting a functional joint leading to articular cartilage disorders. They are advantageous for several reasons and significantly contributed to the understanding of the mechanisms of cartilage diseases among which osteoarthritis. Methods: Literature search in Pubmed. Results and discussion: This narrative review summarizes the most relevant anatomical structural and functional characteristics of the knee (stifle) joints of the major small animal species, including mice, rats, guinea pigs, and rabbits compared with humans. Specific characteristics of each species, including kinematical gait parameters are provided and compared with the human situation. When placed in a proper context respecting their challenges and limitations, small animal models are important and appropriate models for articular cartilage disorders. (C) 2020 Elsevier GmbH. All rights reserved.
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页数：14
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