Combined therapy of ruthenium dendrimers and anti-cancer drugs against human leukemic cells

被引：13

作者：

Michlewska, Sylwia ^{[1
,2
]}

Maroto, Marta ^{[3
,4
]}

Holota, Marcin ^{[2
]}

Kubczak, Malgorzata ^{[2
]}

Sanz del Olmo, Natalia ^{[3
,4
]}

Ortega, Paula ^{[3
,4
,5
]}

Shcharbin, Dzmitry ^{[6
]}

de la Mata, Francisco Javier ^{[3
,4
,5
]}

Bryszewska, Maria ^{[2
]}

Ionov, Maksim ^{[2
]}

机构：

[1] Univ Lodz, Fac Biol & Environm Protect, Lab Microscop Imaging & Specialized Biol Tech, Banacha 12-16, PL-90237 Lodz, Poland

[2] Univ Lodz, Fac Biol & Environm Protect, Dept Gen Biophysics, Pomorska 141-143, PL-90236 Lodz, Poland

[3] Univ Alcala, Dept Organ & Inorgan Chem, Madrid, Spain

[4] Res Inst Chem Andres M del Rio IQAR, Madrid, Spain

[5] Networking Res Ctr Bioengn Biomat & Nanomed CIBER, Madrid, Spain

[6] NASB, Inst Biophys & Cell Engn, Minsk 220072, BELARUS

来源：

DALTON TRANSACTIONS | 2021年 / 50卷 / 27期

基金：

欧盟地平线“2020”;

关键词：

MYELOID-LEUKEMIA; CANCER; METHOTREXATE; COMPLEXES; CHILDREN;

D O I：

10.1039/d1dt01388b

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Carbosilane ruthenium(ii) dendrimers have been complexed with conventional anti-cancer drugs. Due to its features, the presence of ruthenium within a dendrimer structure improves the anti-cancer properties of nanocomplexes containing 5-flurouracyl, methotrexate and doxorubicin. These dendrimers could be promising carriers of anti-cancer medicines. Ruthenium dendrimers that are positively charged can also enhance the cytotoxicity to cancer cells; moreover, they can form stable complexes with drugs. Results indicate that ruthenium dendrimers combined with doxorubicin and methotrexate significantly reduced the viability of leukaemia 1301 and HL-60 cancer cells.

引用

页码：9500 / 9511

页数：12

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