Nanoparticles featuring amino acid-functionalized side chains as DNA receptors

被引：30
|
作者：
Ghosh, Partha S. [1 ]
Han, Gang [1 ]
Erdogan, Belma [1 ]
Rosado, Olga [1 ]
Krovi, Sai Archana [1 ]
Rotello, Vincent M. [1 ]
机构：
[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA
来源：
CHEMICAL BIOLOGY & DRUG DESIGN | 2007年 / 70卷 / 01期
关键词：
amino acid; DNA; nanoparticle;
D O I：
10.1111/j.1747-0285.2007.00534.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A family of nanoparticles has been fabricated featuring cationic amino acid-based side chains. This controlled surface modification provides a tool to investigate the effect of various non-covalent interactions at the nanoparticle-DNA interface. The binding affinities of these nanoparticles towards DNA were determined using fluorescence, exhibiting more than threefold modulation in binding a 37-mer DNA strand. The secondary structure of the DNA strand was distorted upon nanoparticle binding, with the extent of distortion dependent on the structure of amino acid side chain.
引用
收藏
页码：13 / 18
页数：6
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