Preclinical evaluation of a novel non-steroidal glucocorticoid receptor agonist with low systemic exposure and reduced potential for skin atrophy

被引：0
|
作者：
Norsgaard, H. [1 ]
Stahlhut, M. [1 ]
Eirefelt, S. [1 ]
Svitacheva, N. [1 ]
Johnson, P. S. [1 ]
Krogh-Madsen, M. [1 ]
Marstrand, T. T. [1 ]
Ewald, D. A. [1 ]
Dack, K. N. [1 ]
Ollerstam, A. K. [1 ]
机构：
[1] LEO Pharma, Ballerup, Denmark
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2017年 / 137卷 / 10期
关键词：
D O I：
10.1016/j.jid.2017.07.626
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
430
引用
收藏
页码：S266 / S266
页数：1
相关论文
共 29 条
  • [1] Characterization of a novel selective non-steroidal glucocorticoid receptor agonist with low systemic exposure and reduced potential for skin atrophy
    Eirefelt, S.
    Carnerup, M.
    Stahlhut, M.
    Svitacheva, N.
    Ewald, A.
    Marstrand, T.
    Ollerstam, A.
    Norsgaard, H.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2019, 139 (05) : S117 - S117
  • [2] Impact of atropisomerism on a non-steroidal glucocorticoid receptor agonist
    Xu, Zhou
    Wang, Zhongyuan
    Shi, Xiaona
    Ding, Rui
    Han, Li
    Yang, Xueping
    Zhang, Hongmei
    Hobson, Adrian D.
    RSC MEDICINAL CHEMISTRY, 2024, 15 (07): : 2357 - 2371
  • [3] Characterization of a novel non-steroidal glucocorticoid receptor agonist optimized for topical treatment
    Stefan Eirefelt
    Martin Stahlhut
    Naila Svitacheva
    Martin A. Carnerup
    Joel Mauricio Correa Da Rosa
    David Adrian Ewald
    Troels T. Marstrand
    Mikkel Krogh-Madsen
    Georg Dünstl
    Kevin Neil Dack
    Anna Ollerstam
    Hanne Norsgaard
    Scientific Reports, 12
  • [4] Characterization of a novel non-steroidal glucocorticoid receptor agonist optimized for topical treatment
    Eirefelt, Stefan
    Stahlhut, Martin
    Svitacheva, Naila
    Carnerup, Martin A.
    Da Rosa, Joel Mauricio Correa
    Ewald, David Adrian
    Marstrand, Troels T.
    Krogh-Madsen, Mikkel
    Dunstl, Georg
    Dack, Kevin Neil
    Ollerstam, Anna
    Norsgaard, Hanne
    SCIENTIFIC REPORTS, 2022, 12 (01)
  • [5] Characterization of a novel non-steroidal glucocorticoid receptor antagonist
    Li, Qun-Yi
    Zhang, Meng
    Hallis, Tina M.
    DeRosier, Therese A.
    Yue, Jian-Min
    Ye, Yang
    Mais, Dale E.
    Wang, Ming-Wei
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 391 (03) : 1531 - 1536
  • [6] Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators
    Ray, Nicholas C.
    Clark, Robin D.
    Clark, David E.
    Williams, Karen
    Hickin, H. G.
    Crackett, Peter H.
    Dyke, Hazel J.
    Lockey, Peter M.
    Wong, Melanie
    Devos, Rene
    White, Anne
    Belanoff, Joseph K.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (17) : 4901 - 4905
  • [7] The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist
    Rimland, Joseph
    Dunne, Angela
    Hunjan, Suchete S.
    Sasse, Rosemary
    Uings, Iain
    Montanari, Dino
    Caivano, Matilde
    Shah, Poonam
    Standing, David
    Gray, David
    Brown, David
    Cairns, William
    Trump, Ryan
    Smith, Paul W.
    Bertheleme, Nicolas
    D'Alessandro, Pier
    Gul, Sheraz
    Vimal, Mythily
    Smith, David N.
    Watson, Stephen P.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (07) : 2340 - 2343
  • [8] Discovery of indazole ethers as novel, potent, non-steroidal glucocorticoid receptor modulators
    Hemmerling, Martin
    Edman, Karl
    Lepisto, Matti
    Eriksson, Anders
    Ivanova, Svetlana
    Dahmen, Jan
    Rehwinkel, Hartmut
    Berger, Markus
    Hendrickx, Ramon
    Dearman, Matthew
    Jensen, Tina Jellesmark
    Wissler, Lisa
    Hansson, Thomas
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (23) : 5741 - 5748
  • [9] Discovery of a potent and dissociated non-steroidal glucocorticoid receptor agonist containing an alkyl carbinol pharmacophore
    Razavi, Hossein
    Riether, Doris
    Harcken, Christian
    Bentzien, Joerg
    Dinallo, Roger M.
    Souza, Donald
    Nelson, Richard M.
    Kukulka, Alison
    Fadra-Khan, Tazmeen N.
    Pack, Edward J., Jr.
    Zuvela-Jelaska, Ljiljana
    Pelletier, Josephine
    Panzenbeck, Mark
    Torcellini, Carol A.
    Proudfoot, John R.
    Nabozny, Gerald H.
    Thomson, David S.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (08) : 1934 - 1940
  • [10] The first X-ray crystal structure of the glucocorticoid receptor bound to a non-steroidal agonist
    Madauss, Kevin P.
    Bledsoe, Randy K.
    Mclay, Iain
    Stewart, Eugene L.
    Uings, Iain J.
    Weingarten, Gordon
    Williams, Shawn P.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (23) : 6097 - 6099
123