The suggestion of a risk stratification system for febrile neutropenia in patients with hematologic disease

被引：10

作者：

Park, Yong ^{[1
]}

Kim, Dae Sik ^{[1
]}

Park, Seh Jong ^{[1
]}

Seo, Hee Yun ^{[1
]}

Lee, Se Ryeon ^{[1
]}

Sung, Hwa Jung ^{[1
]}

Park, Kyong Hwa ^{[1
]}

Choi, In Keun ^{[1
]}

Kim, Seok Jin ^{[2
]}

Oh, Sang Cheul ^{[1
]}

Seo, Jae Hong ^{[1
]}

Choi, Chul Won ^{[1
]}

Kim, Byung Soo ^{[1
]}

Shin, Sang Won ^{[1
]}

Kim, Yeul Hong ^{[1
]}

Kim, Jun Suk ^{[1
]}

机构：

[1] Korea Univ, Med Ctr, Dept Internal Med, Div Hematol & Oncol,Coll Med, Seoul 136705, South Korea

[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Hematol & Oncol,Dept Med, Seoul, South Korea

来源：

LEUKEMIA RESEARCH | 2010年 / 34卷 / 03期

关键词：

Febrile neutropenia; Prognosis; Hematologic malignancy; Albumin; Bicarbonate; C-reactive protein; C-REACTIVE PROTEIN; NON-HODGKINS-LYMPHOMA; CANCER-PATIENTS; MULTINATIONAL-ASSOCIATION; SUPPORTIVE-CARE; PROGNOSTIC SCORE; INFECTION; MORTALITY; THERAPY; NEPHROTOXICITY;

D O I：

10.1016/j.leukres.2009.08.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We analyzed the prognostic factors from 259 cases of febrile neutropenia occurring in 137 patients with hematologic disease. Based on multivariate analysis, significant prognostic factors are recovery of neutropenia, respiratory infection, baseline serum albumin, baseline bicarbonate, baseline CRP, and CRP on the fifth day after antibiotic treatment. From these variables, we derived a predictive model for the prognosis of febrile neutropenia using baseline serum albumin, bicarbonate, and CRP, which could be easily checked before chemotherapy. Further studies in prospective setting are needed for the validation of this model. (C) 2009 Published by Elsevier Ltd.

引用

页码：294 / 300

页数：7

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