Animal Models of Substance Abuse and Addiction: Implications for Science, Animal Welfare, and Society

被引：0

作者：

Lynch, Wendy J. ^{[2
]}

Nicholson, Katherine L. ^{[3
]}

Dance, Mario E. ^{[4
]}

Morgan, Richard W. ^{[2
]}

Foley, Patricia L. ^{[1
]}

机构：

[1] Univ Virginia, Off Anim Welf, Charlottesville, VA 22903 USA

[2] Univ Virginia, Dept Psychiat & Neurobehav Sci, Charlottesville, VA USA

[3] Virginia Commonwealth Univ, Dept Pharmacol & Toxicol, Richmond, VA USA

[4] Virginia Commonwealth Univ, Div Anim Resources, Richmond, VA USA

来源：

COMPARATIVE MEDICINE | 2010年 / 60卷 / 03期

关键词：

CONDITIONED PLACE PREFERENCE; SELF-ADMINISTERED COCAINE; INTRAVENOUS PHARMACOKINETIC PARAMETERS; LOW SACCHARIN INTAKE; RHESUS-MONKEYS; DISCRIMINATIVE STIMULUS; SEX-DIFFERENCES; SEEKING BEHAVIOR; EXTENDED-ACCESS; QUALITATIVE EVALUATION;

D O I：

暂无

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Substance abuse and addiction are well recognized public health concerns, with 2 NIH institutes (the National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism) specifically targeting this societal problem. As such, this is an important area of research for which animal experiments play a critical role. This overview presents the importance of substance abuse and addiction in society; reviews the development and refinement of animal models that address crucial areas of biology, pathophysiology, clinical treatments, and drug screening for abuse liability; and discusses some of the unique veterinary, husbandry, and IACUC challenges associated with these models.

引用

页码：177 / 188

页数：12

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