Titer Optimization of Lentiviral Vectors Encoding the Human beta-Globin Gene for Clinical Use

被引：0
|
作者：
Wang, Xiuyan [1 ]
Lisowski, Leszek [2 ]
Olszewska, Malgorzata [1 ]
Plotkin, Jason [2 ]
Ferro, Leda [1 ]
Papapetrou, Eirini [2 ]
Riviere, Isabelle [1 ,3 ,4 ]
Sadelain, Michel [1 ,2 ,3 ,4 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Gene Transfer & Somat Cell Engn Facil, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Gene Transfer & Gene Express Lab, New York, NY 10021 USA
[3] Mem Sloan Kettering Canc Ctr, Ctr Cell Engn, New York, NY 10021 USA
[4] Mem Sloan Kettering Canc Ctr, Mol Pharmacol & Chem Program, New York, NY 10021 USA
来源：
MOLECULAR THERAPY | 2009年 / 17卷
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
引用
收藏
页码：S172 / S172
页数：1
相关论文
共 50 条
  • [1] RETROVIRAL VECTORS FOR THE BETA-GLOBIN GENE THAT DEMONSTRATE IMPROVED TITER AND EXPRESSION
    GELINAS, R
    NOVAK, U
    [J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1990, 612 : 427 - 441
  • [2] Lentiviral and retroviral vectors for transcriptionally targeted expression of human beta-globin
    Miccio, A
    Facchini, G
    Lotti, F
    Rossi, C
    Ferrari, G
    [J]. MOLECULAR THERAPY, 2004, 9 : S380 - S380
  • [3] DESIGN OF RETROVIRUS VECTORS FOR TRANSFER AND EXPRESSION OF THE HUMAN BETA-GLOBIN GENE
    MILLER, AD
    BENDER, MA
    HARRIS, EAS
    KALEKO, M
    GELINAS, RE
    [J]. JOURNAL OF VIROLOGY, 1988, 62 (11) : 4337 - 4345
  • [4] POLYMORPHISM OF THE HUMAN BETA-GLOBIN GENE
    ANTONARAKIS, SE
    ORKIN, SH
    KAZAZIAN, HH
    BOEHM, CD
    WABER, PG
    GOFF, SC
    SEXTON, JP
    [J]. CLINICAL RESEARCH, 1982, 30 (02): : A499 - A499
  • [5] MURPHY LAW AND THE HUMAN BETA-GLOBIN GENE
    VIGUE, CL
    [J]. AMERICAN BIOLOGY TEACHER, 1987, 49 (02): : 76 - 81
  • [6] Optimization of the beta-globin LCR and promoter elements for lentiviral vector-encoded the beta-globin transgene expression in beta-thalassemic mice
    Lisowski, Leszek
    Sadelain, Michel
    [J]. BLOOD CELLS MOLECULES AND DISEASES, 2008, 40 (02) : 274 - 274
  • [7] GENE DELETION DISTANT FROM THE BETA-GLOBIN LOCUS INACTIVATES THE BETA-GLOBIN GENE
    PIRASTU, M
    CURTIN, P
    KAN, YW
    GOBERTJONES, JA
    STEPHENS, AD
    LEHMANN, H
    [J]. CLINICAL RESEARCH, 1984, 32 (02): : A493 - A493
  • [8] HUMAN BETA-GLOBIN GENE-EXPRESSION AFTER GENE-TRANSFER USING RETROVIRAL VECTORS
    LERNER, N
    BRIGHAM, S
    GOFF, S
    BANK, A
    [J]. DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY, 1987, 6 (06): : 573 - 582
  • [9] INACTIVATION OF THE HUMAN BETA-GLOBIN GENE BY TARGETED INSERTION INTO THE BETA-GLOBIN LOCUS-CONTROL REGION
    KIM, CG
    EPNER, EM
    FORRESTER, WC
    GROUDINE, M
    [J]. GENES & DEVELOPMENT, 1992, 6 (06) : 928 - 938
  • [10] STRUCTURE OF THE HUMAN BETA-GLOBIN GENE IN BETA-THALASSEMIA
    FLAVELL, RA
    BERNARDS, R
    KOOTER, JM
    BOER, E
    LITTLE, PFR
    ANNISON, G
    WILLIAMSON, R
    [J]. NUCLEIC ACIDS RESEARCH, 1979, 6 (08) : 2749 - 2760
12345