Continuous Reductions and Reductive Aminations Using Solid NaBH4

被引：28

作者：

Gilmore, Kerry ^{[1
]}

Vukelic, Stella ^{[2
]}

McQuade, D. Tyler ^{[1
,3
]}

Koksch, Beate ^{[2
]}

Seeberger, Peter H. ^{[1
]}

机构：

[1] Max Planck Inst Colloids & Interfaces, D-14476 Potsdam, Germany

[2] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany

[3] Florida State Univ, Dept Chem & Biochem, Tallahassee, FL 32306 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2014年 / 18卷 / 12期

关键词：

FLOW CHEMISTRY; SELECTIVE REDUCTION; CARBONYL-COMPOUNDS; ALDEHYDES; KETONES; CATALYSTS; VERSATILE; TECHNOLOGY; COMPLEXES; EFFICIENT;

D O I：

10.1021/op500310s

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Most successful reactions carried out under continuous flow conditions mix homogeneous solutions yielding homogeneous products. Using solids is avoided to prevent pump and reactor clogging; even though solid reagents may often be the best choice for a given transformation. Here we demonstrate that by pumping aldehydes, ketones, or in situ formed imines through a specially formulated NaBH4 column results in efficient reductions. The column design and performance characteristics, along with substrate scope, are discussed.

引用

页码：1771 / 1776

页数：6

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