Photothermal Effects of Supramolecularly Assembled Gold Nanoparticles for the Targeted Treatment of Cancer Cells

被引：226
|
作者：
Wang, Shutao [1 ]
Chen, Kuan-Ju [1 ]
Wu, Ting-Hsiang [3 ]
Wang, Hao [1 ]
Lin, Wei-Yu [1 ]
Ohashi, Minori [1 ]
Chiou, Pei-Yu [2 ]
Tseng, Hsian-Rong [1 ]
机构：
[1] Univ Calif Los Angeles, CIMI, Dept Mol & Med Pharmacol, CNSI,Inst Mol Med IMED, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Mech & Aerosp Engn, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Dept Elect Engn, Los Angeles, CA 90095 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 22期
基金：
美国国家科学基金会;
关键词：
gold; nanoparticles; photothermal effects; self-assembly; tumor therapy; OPTICAL-PROPERTIES; CARBON NANOTUBES; NANO-THERMOLYSIS; THERAPY PPTT; ELIMINATION; NANOCAGES; ABLATION; CLUSTERS; POLYMER; HEAT;
D O I：
10.1002/anie.201000062
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) Laser-triggered nanobomb: Size-controlled gold supramolecular nanoparticles (Au-SNPs) were synthesized from 2 nm gold colloids by a supramolecular selfassembly approach. These Au-SNPs exhibited significantly enhanced photothermal effects and could be used in conjunction with laser irradiation for the selective destruction of cancer cells (see picture) after the incorporation of a targetspecific ligand. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：3777 / 3781
页数：5
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