Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation

被引:26
|
作者
Oikonomou, Nikos [1 ,2 ]
Schuijs, Martjin J. [3 ]
Chatzigiagkos, Antonis [1 ,2 ]
Androulidaki, Ariadne [1 ,2 ]
Aidinis, Vassilis [4 ]
Hammad, Hamida [3 ,5 ]
Lambrecht, Bart N. [3 ,5 ,6 ]
Pasparakis, Manolis [1 ,2 ]
机构
[1] Univ Cologne, Inst Genet, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany
[2] Univ Cologne, Ctr Mol Med, Cologne, Germany
[3] VIB UGent Ctr Inflammat Res, Lab Immunoregulat & Mucosal Immunol, Ghent, Belgium
[4] Biomed Sci Res Ctr Alexander Fleming, Vari, Greece
[5] Univ Ghent, Dept Internal Med & Pediat, Ghent, Belgium
[6] Erasmus MC, Dept Pulm Med, Rotterdam, Netherlands
关键词
CREOLA BODIES; CASPASE-8; DEATH; HOMEOSTASIS; APOPTOSIS; RELEASE; INTERLEUKIN-1-ALPHA; EXPRESSION; TRIGGERS; IMMUNITY;
D O I
10.1038/s41385-021-00415-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Regulation of epithelial cell death has emerged as a key mechanism controlling immune homeostasis in barrier surfaces. Necroptosis is a type of regulated necrotic cell death induced by receptor interacting protein kinase 3 (RIPK3) that has been shown to cause inflammatory pathologies in different tissues. The role of regulated cell death and particularly necroptosis in lung homeostasis and disease remains poorly understood. Here we show that mice with Airway Epithelial Cell (AEC)-specific deficiency of Fas-associated with death domain (FADD), an adapter essential for caspase-8 activation, developed exacerbated allergic airway inflammation in a mouse model of asthma induced by sensitization and challenge with house dust mite (HDM) extracts. Genetic inhibition of RIPK1 kinase activity by crossing to mice expressing kinase inactive RIPK1 as well as RIPK3 or MLKL deficiency prevented the development of exaggerated HDM-induced asthma pathology in FADD(AEC-KO) mice, suggesting that necroptosis of FADD-deficient AECs augmented the allergic immune response. These results reveal a role of AEC necroptosis in amplifying airway allergic inflammation and suggest that necroptosis could contribute to asthma exacerbations caused by respiratory virus infections inducing AEC death.
引用
收藏
页码:1160 / 1171
页数:12
相关论文
共 50 条
  • [1] House dust mite-induced allergic airway inflammation in a mouse model
    Gilliam, GJ
    Agrawal, DK
    [J]. FASEB JOURNAL, 2004, 18 (05): : A1128 - A1128
  • [2] Intranasal prostaglandin E2 reduces airway inflammation in a house dust mite-induced mouse model of allergic asthma
    Herrerias, A.
    Torres, R.
    Marco, A.
    Picado, C.
    de Mora, F.
    [J]. ALLERGY, 2008, 63 : 115 - 116
  • [3] RNA-Binding Protein HuR Promotes Airway Inflammation in a House Dust Mite-Induced Allergic Asthma Model
    Herjan, Tomasz
    Xiao, Jianxin
    Dziendziel Kolanek, Monika
    [J]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2022, 42 (01): : 29 - 38
  • [4] IRAK-M knockout promotes allergic airway inflammation, but not airway hyperresponsiveness, in house dust mite-induced experimental asthma model
    Zhang, Xudong
    Zhang, Mingqiang
    Li, Lun
    Chen, Wei
    Zhou, Wexun
    Gao, Jinming
    [J]. JOURNAL OF THORACIC DISEASE, 2021, 13 (03) : 1413 - 1426
  • [5] Intermittent hypoxic pretreatment exacerbates house dust mite-induced asthma airway inflammation
    Meng, Hao
    Zhang, Dongxue
    Que, Yifan
    Hu, Peng
    Wang, Runsheng
    Liao, Yunfei
    Xu, Guogang
    [J]. IMMUNITY INFLAMMATION AND DISEASE, 2024, 12 (04)
  • [6] Interleukin-33 from Monocytes Recruited to the Lung Contributes to House Dust Mite-Induced Airway Inflammation in a Mouse Model
    Tashiro, Hiroki
    Takahashi, Koichiro
    Hayashi, Shinichiro
    Kato, Go
    Kurata, Keigo
    Kimura, Shinya
    Sueoka-Aragane, Naoko
    [J]. PLOS ONE, 2016, 11 (06):
  • [7] Rapid development of house dust mite-induced allergic inflammation
    Kaminuma, Osamu
    [J]. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2016, 130 (03) : S38 - S38
  • [8] Protective Roles for RGS2 in a Mouse Model of House Dust Mite-Induced Airway Inflammation
    George, Tresa
    Bell, Matthew
    Chakraborty, Mainak
    Siderovski, David P.
    Giembycz, Mark A.
    Newton, Robert
    [J]. PLOS ONE, 2017, 12 (01):
  • [9] Schistosoma japonicum infection downregulates house dust mite-induced allergic airway inflammation in mice
    Qiu, Sugan
    Fan, Xiaolin
    Yang, Yingying
    Dong, Panpan
    Zhou, Wei
    Xu, Yongliang
    Zhou, Yonghua
    Guo, Fukun
    Zheng, Yi
    Yang, Jun-Qi
    [J]. PLOS ONE, 2017, 12 (06):
  • [10] Allergin-1 Immunoreceptor Suppresses House Dust Mite-Induced Allergic Airway Inflammation
    Miki, Haruka
    Tahara-Hanaoka, Satoko
    Almeida, Mariana Silva
    Hitomi, Kaori
    Shibagaki, Shohei
    Kanemaru, Kazumasa
    Lin, Yu-Hsien
    Iwata, Kanako
    Miyake, Shota
    Shibayama, Shiro
    Sumida, Takayuki
    Shibuya, Kazuko
    Shibuya, Akira
    [J]. JOURNAL OF IMMUNOLOGY, 2020, 204 (04): : 753 - 762