Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish

被引：42

作者：

Appenzeller-Herzog, Christian ^{[1
]}

Banhegyi, Gabor ^{[2
]}

Bogeski, Ivan ^{[3
]}

Davies, Kelvin J. A. ^{[4
,5
]}

Delaunay-Moisan, Agnes ^{[6
]}

Forman, Henry Jay ^{[4
,5
]}

Goerlach, Agnes ^{[7
]}

Kietzmann, Thomas ^{[8
]}

Laurindo, Francisco ^{[9
]}

Margittai, Eva ^{[10
]}

Meyer, Andreas J. ^{[11
]}

Riemer, Jan ^{[12
]}

Rutzler, Michael ^{[13
]}

Simmen, Thomas ^{[14
]}

Sitia, Roberto ^{[15
]}

Toledano, Michel B. ^{[6
]}

Touw, Ivo P. ^{[16
]}

机构：

[1] Berufsfachschule Gesundheit Baselland, CH-4142 Munchenstein, Switzerland

[2] Semmelweis Univ, Dept Med Chem Mol Biol & Pathobiochem, H-1428 Budapest, Hungary

[3] Univ Saarland, Sch Med, Dept Biophys, D-66421 Homburg, Germany

[4] Univ So Calif, Ethel Percy Andrus Gerontol Ctr, Leonard Davis Sch Gerontol, Los Angeles, CA 90089 USA

[5] Univ So Calif, Dornsife Coll Letters Arts & Sci, Dept Biol Sci, Div Mol & Computat Biol, Los Angeles, CA 90089 USA

[6] CEA Saclay, Lab Stress Oxydant & Canc, I2BC, F-91198 Gif Sur Yvette, France

[7] Tech Univ Munich, German Heart Ctr Munich, Expt & Mol Pediat Cardiol, D-80636 Munich, Germany

[8] Univ Oulu, Fac Biochem & Mol Med, Oulu 90210, Finland

[9] Univ Sao Paulo, Sch Med, Inst Heart, Vasc Biol Lab, BR-05403000 Sao Paulo, Brazil

[10] Semmelweis Univ, Inst Human Physiol & Clin Expt Res, H-1428 Budapest, Hungary

[11] Univ Bonn, INRES Chem Signalling, D-53113 Bonn, Germany

[12] Univ Cologne, Inst Biochem, D-50674 Cologne, Germany

[13] Aalborg Univ, Inst Hlth Sci & Technol, DK-9220 Aalborg, Denmark

[14] Univ Alberta, Fac Med & Dent, Dept Cell Biol, Edmonton, AB T6G 2H7, Canada

[15] Univ Vita Salute San Raffaele, Osped San Raffaele, IRCCS, Prot Transport & Secret Unit,Div Genet & Cell Bio, I-20132 Milan, Italy

[16] Erasmus Univ, Med Ctr, Dept Hematol, POB 2040, Rotterdam, Netherlands

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2016年 / 94卷

关键词：

PROTEIN-TYROSINE PHOSPHATASES; AQUAPORIN-11 KNOCKOUT MICE; GLUTATHIONE-PEROXIDASE; 7; HYDROGEN-PEROXIDE; DNA-DAMAGE; REDOX REGULATION; NOX4; RECEPTOR; INACTIVATION; VACUOLIZATION;

D O I：

10.1016/j.freeradbiomed.2016.02.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cellular metabolism provides various sources of hydrogen peroxide (H2O2) in different organelles and compartments. The suitability of H2O2 as an intracellular signaling molecule therefore also depends on its ability to pass cellular membranes. The propensity of the membranous boundary of the endoplasmic reticulum (ER) to let pass H2O2 has been discussed controversially. In this essay, we challenge the recent proposal that the ER membrane constitutes a simple barrier for H2O2 diffusion and support earlier data showing that (i) ample H2O2 permeability of the ER membrane is a prerequisite for signal transduction, (ii) aquaporin channels are crucially involved in the facilitation of H2O2 permeation, and (iii) a proper experimental framework not prone to artifacts is necessary to further unravel the role of H2O2 permeation in signal transduction and organelle biology. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：157 / 160

页数：4

共 50 条

[1] Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane
Bestetti, Stefano
Galli, Mauro
Sorrentino, Ilaria
Pinton, Paolo
Rimessi, Alessandro
Sitia, Roberto
Medrano-Fernandez, Iria
REDOX BIOLOGY, 2020, 28
[2] Quercetin attenuates the effects of H2O2 on endoplasmic reticulum morphology and tyrosinase export from the endoplasmic reticulum in melanocytes
Guan, Cuiping
Xu, Wen
Hong, Weisong
Zhou, Miaoni
Lin, Fuquan
Fu, Lifang
Liu, Dongyin
Xu, Aie
MOLECULAR MEDICINE REPORTS, 2015, 11 (06) : 4285 - 4290
[3] Exquisite sensitivity of Polycystin-1 to H2O2 concentration in the endoplasmic reticulum
Speranza, Elisa
Sorrentino, Ilaria
Boletta, Alessandra
Sitia, Roberto
REDOX BIOLOGY, 2025, 80
[4] Production of H2O2 in the Endoplasmic Reticulum Promotes In Vivo Disulfide Bond Formation
Margittai, Eva
Loew, Peter
Stiller, Ibolya
Greco, Alessandra
Garcia-Manteiga, Jose Manuel
Pengo, Niccolo
Benedetti, Angelo
Sitia, Roberto
Banhegyi, Gabor
ANTIOXIDANTS & REDOX SIGNALING, 2012, 16 (10) : 1088 - 1099
[5] Intracellular Sources of ROS/H2O2 in Health and Neurodegeneration: Spotlight on Endoplasmic Reticulum
Konno, Tasuku
Melo, Eduardo Pinho
Chambers, Joseph E.
Avezov, Edward
CELLS, 2021, 10 (02) : 1 - 26
[6] Transfer of H2O2 from Mitochondria to the endoplasmic reticulum via Aquaporin-11
Sorrentino, Ilaria
Galli, Mauro
Medrano-Fernandez, Iria
Sitia, Roberto
REDOX BIOLOGY, 2022, 55
[7] TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H2O2
Eduardo Pinho Melo
Carlos Lopes
Peter Gollwitzer
Stephan Lortz
Sigurd Lenzen
Ilir Mehmeti
Clemens F. Kaminski
David Ron
Edward Avezov
BMC Biology, 15
[8] TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H2O2
Melo, Eduardo Pinho
Lopes, Carlos
Gollwitzer, Peter
Lortz, Stephan
Lenzen, Sigurd
Mehmeti, Ilir
Kaminski, Clemens F.
Ron, David
Avezov, Edward
BMC BIOLOGY, 2017, 15
[9] GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum
Ramming, Thomas
Hansen, Henning G.
Nagata, Kazuhiro
Ellgaard, Lars
Appenzeller-Herzog, Christian
FREE RADICAL BIOLOGY AND MEDICINE, 2014, 70 : 106 - 116
[10] Endoplasmic Reticulum-Directed Ratiometric Fluorescent Probe for Quantitive Detection of Basal H2O2
Gao, Congcong
Tian, Yong
Zhang, Rubo
Jing, Jing
Zhang, Xiaoling
ANALYTICAL CHEMISTRY, 2017, 89 (23) : 12945 - 12950

← 1 2 3 4 5 →