Oligodendrocyte-specific protein (OSP) is a major component of CNS myelin

被引:0
|
作者
Bronstein, JM
Micevych, PE
Chen, K
机构
[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT NEUROBIOL,LOS ANGELES,CA 90024
[2] UNIV CALIF LOS ANGELES,INST BRAIN RES,LOS ANGELES,CA 90024
关键词
myelin; PMP-22; PLP/DM20; glycoprotein;
D O I
10.1002/(SICI)1097-4547(19971201)50:5<713::AID-JNR8>3.0.CO;2-K
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
An oligodendrocyte-specific protein (OSP) cDNA was recently identified and found to be expressed primarily in oligodendrocytes and has a deduced amino acid sequence similar to that of peripheral myelin protein 22 (PMP-22). We raised antibodies against a synthetic peptide corresponding to OSP amino acid residues 179-194 which reacted with a 22 kd protein in mouse CNS, OSP immunoreactivity localized to spinal cord white matter tracts using immunohistochemistry in a similar distribution to that of MBP. OSP localized to CNS myelin biochemically with more than a 30-fold enrichment measured in purified myelin. We further purified the proteolipid fraction of myelin and determined that OSP contributes approximately 7% of total myelin protein making it the third most abundant protein in CNS myelin. No binding was found to several agglutinins or a HNK1-specific antibody suggesting that OSP is not a glycoprotein. (C) 1997 Wiley-Liss, Inc.
引用
收藏
页码:713 / 720
页数:8
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