An Efficient One-Pot Synthesis of Substituted 2-Aminothiophenes via Three-Component Gewald Reaction Catalyzed by L-Proline

被引：60

作者：

Wang, Tao ^{[1
,2
]}

Huang, Xian-Gui ^{[1
,2
]}

Liu, Jia ^{[1
,2
]}

Li, Bo ^{[4
]}

Wu, Jin-Jin ^{[1
]}

Chen, Kai-Xian ^{[4
]}

Zhu, Wei-Liang ^{[1
,3
]}

Xu, Xiao-Yong ^{[1
,2
]}

Zeng, Bu-Bing ^{[1
,2
]}

机构：

[1] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

[2] Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

[3] Shanghai Inst Mat Med, Drug Discovery & Design Ctr, Shanghai 201203, Peoples R China

[4] Shanghai Univ Tradit Chinese Med, Shanghai 201203, Peoples R China

来源：

SYNLETT | 2010年 / 09期

关键词：

Gewald reaction; 2-aminothiophene; one-pot; multi-component; Knoevenagel reaction; ORGANOCATALYTIC MULTICOMPONENT REACTIONS; ALLOSTERIC ENHANCERS; THIOPHENES; INHIBITORS; CYCLOADDITION; BINDING; SULFUR;

D O I：

10.1055/s-0029-1219917

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient one-pot procedure for the direct catalytic synthesis of substituted 2-aminothiophenes catalyzed by L-proline under mild reaction conditions has been developed. A variety of functionalized 2-aminothiophene scaffolds were assembled in high yields by this catalytic protocol. Low catalyst loading, simple procedure, and high yields are the important attributes of this methodology.

引用

页码：1351 / 1354

页数：4

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