NEDD4-2 (NEDD4L): The ubiquitin ligase for multiple membrane proteins

被引：130

作者：

Goel, Pranay ^{[1
,2
]}

Manning, Jantina A. ^{[1
]}

Kumar, Sharad ^{[1
,2
]}

机构：

[1] Univ S Australia, Ctr Canc Biol, Adelaide, SA 5001, Australia

[2] Univ Adelaide, Dept Med, Adelaide, SA 5005, Australia

来源：

GENE | 2015年 / 557卷 / 01期

基金：

英国医学研究理事会;

关键词：

Ubiquitin; Ubiquitin protein ligases; NEDD4; family; Epithelial sodium channel (ENaC); Voltage-gated sodium channels (Na(v)s); Hypertension; EPITHELIAL NA+ CHANNEL; GATED SODIUM-CHANNELS; TIGHT JUNCTION FORMATION; DOWN-REGULATION; SURFACE EXPRESSION; NEDD4-2-MEDIATED INHIBITION; POTASSIUM CHANNEL; GENETIC-VARIATION; ENAC REGULATION; HERG CHANNEL;

D O I：

10.1016/j.gene.2014.11.051

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

NEDD4-2 (also known as NEDD4L, neural precursor cell expressed developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family which is known to bind and regulate a number of membrane proteins to aid in their internalization and turnover. Several of the NEDD4-2 substrates include ion channels, such as the epithelial and voltage-gated sodium channels. Given the critical function of NEDD4-2 in regulating membrane proteins, this ligase is essential for the maintenance of cellular homeostasis. In this article we review the biology and function of this important ubiquitin-protein ligase and discuss its pathophysiological significance. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：1 / 10

页数：10

共 50 条

[1] Oligomerization of the HECT ubiquitin ligase NEDD4-2/NEDD4L is essential for polyubiquitin chain assembly
Todaro, Dustin R.
Augustus-Wallace, Allison C.
Klein, Jennifer M.
Haas, Arthur L.
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (47) : 18192 - 18206
[2] Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma
Kito, Yusuke
Bai, Juncheng
Goto, Naoe
Okubo, Hiroshi
Adachi, Yoshihiro
Nagayama, Tomoko
Takeuchi, Tamotsu
[J]. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 2014, 95 (01) : 24 - 28
[3] Association of NEDD4L ubiquitin ligase with essential hypertension
Russo, CJ
Melista, E
Cui, J
DeStefano, AL
Bakris, GL
Manolis, AJ
Gavras, H
Baldwin, CT
[J]. HYPERTENSION, 2005, 46 (03) : 488 - 491
[4] The Nedd4L ubiquitin ligase is activated by FCHO2-generated membrane curvature
Sakamoto, Yasuhisa
Uezu, Akiyoshi
Kikuchi, Koji
Kang, Jangmi
Fujii, Eiko
Moroishi, Toshiro
Suetsugu, Shiro
Nakanishi, Hiroyuki
[J]. EMBO JOURNAL, 2024,
[5] The E3 ubiquitin ligase, NEDD4L (NEDD4-2) regulates bestrophin-1 (BEST1) by ubiquitin-dependent proteolysis
Park, Myeongki
Jung, Hyun-Gug
Kweon, Hae-Jin
Kim, Yeong-Eun
Park, Jae-Yong
Hwang, Eun Mi
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 514 (01) : 344 - 350
[6] Characterization of the HECT Domain Ubiquitin Ligase Nedd4-2
Velivela, Swetha Devi
Kane, Patricia M.
[J]. FASEB JOURNAL, 2016, 30
[7] The ubiquitin ligase NEDD4-2/NEDD4L regulates both sodium homeostasis and fibrotic signaling to prevent end-stage renal disease
Jantina A. Manning
Sonia S. Shah
Andrej Nikolic
Tanya L. Henshall
Yeesim Khew-Goodall
Sharad Kumar
[J]. Cell Death & Disease, 12
[8] The ubiquitin ligase NEDD4-2/NEDD4L regulates both sodium homeostasis and fibrotic signaling to prevent end-stage renal disease
Manning, Jantina A.
Shah, Sonia S.
Nikolic, Andrej
Henshall, Tanya L.
Khew-Goodall, Yeesim
Kumar, Sharad
[J]. CELL DEATH & DISEASE, 2021, 12 (04)
[9] The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1
Zhu, Jun-yi
Heidersbach, Amy
Kathiriya, Irfan S.
Garay, Bayardo I.
Ivey, Kathryn N.
Srivastava, Deepak
Han, Zhe
King, Isabelle N.
[J]. DEVELOPMENT, 2017, 144 (05): : 866 - 875
[10] Investigation of the possible association of NEDD4-2 (NEDD4L) gene with idiopathic photosensitive epilepsy
Vanli-Yavuz, Ebru Nur
Ozdemir, Ozkan
Demirkan, Ayse
Catal, Suzin
Bebek, Nerses
Ozbek, Ugur
Baykan, Betul
[J]. ACTA NEUROLOGICA BELGICA, 2015, 115 (03) : 241 - 245

← 1 2 3 4 5 →