Assessing Herd Immunity in the Elderly Following the Vaccination of School Children with Live Attenuated Trivalent Influenza Vaccine (LAIV): A County-Level Analysis

被引：5
|
作者：
Hull, Harry F. [1 ]
McBean, A. Marshall [2 ]
Caldwell, Debra [2 ]
O'Connor, Heidi [1 ,2 ]
机构：
[1] HF Hull & Associates, St Paul, MN USA
[2] Univ Minnesota, Sch Publ Hlth, Minneapolis, MN USA
来源：
3RD VACCINE GLOBAL CONGRESS, SINGAPORE 2009 | 2010年 / 2卷 / 01期
关键词：
OLDER-ADULTS; IMMUNIZATION; POPULATION; PROTECTION; IMPACT; RECOMMENDATIONS; PREVENTION; MORBIDITY; COMMITTEE; BENEFITS;
D O I：
10.1016/j.provac.2010.03.017
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immunizing children could reduce influenza in the elderly. We compared pneumonia and influenza hospitalizations (P&I) and medically attended acute respiratory infections (MAARI) in the Medicare populations in 1 Tennessee and 3 Minnesota counties that immunized school children with live, attenuated influenza vaccine with 4 comparison counties. The P&I rate ratio (RR) of intervention county/comparison county in Tennessee in 200506 was 0.74 (95% CI 0.61 - 0.87 which was significantly lower than the previous 5 years. With low influenza activity in 200607, P&I RRs for both states were not lower than the pre-intervention years. MAARI RRs in both states did not differ from the preintervention periods. Immunizing children against influenza may reduce P&I for the elderly in seasons when influenza outbreaks are severe. Additional study is needed before immunizing children against influenza can be recommended for herd immunity. (C) 2010 Published by Elsevier Ltd.
引用
收藏
页码：92 / 100
页数：9
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