The Global Impact of Hepatitis B Vaccination on Hepatocellular Carcinoma

被引:34
|
作者
Flores, Joan Ericka [1 ,2 ]
Thompson, Alexander J. [1 ,2 ,3 ]
Ryan, Marno [1 ,2 ,3 ]
Howell, Jessica [1 ,2 ,3 ,4 ]
机构
[1] St Vincents Hosp Melbourne, Dept Gastroenterol, Fitzroy, Vic 3065, Australia
[2] Univ Melbourne, Dept Med, Parkville, Vic 3010, Australia
[3] Burnet Inst, Dis Eliminat Program, Melbourne, Vic 3004, Australia
[4] Monash Univ, Dept Epidemiol & Preventat Med, Clayton, Vic 3800, Australia
关键词
hepatitis B; vaccination; hepatocellular carcinoma; public health; CONTROLLED TEMPERATURE CHAIN; SUB-SAHARAN AFRICA; LIVER-CANCER; CHILDHOOD IMMUNIZATION; VIRUS-INFECTION; HOME DELIVERY; ELIMINATION; PREVENTION; PROGRAM; EPIDEMIOLOGY;
D O I
10.3390/vaccines10050793
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Over 1.5 million preventable new hepatitis B infections continue to occur each year and there are an estimated 296 million people living with chronic hepatitis B infection worldwide, resulting in more than 820,000 deaths annually due to liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B vaccination remains the cornerstone of public health policy to prevent HCC and a vital component of the global hepatitis B elimination response. The WHO has set a 90% vaccination target to achieve hepatitis B elimination by 2030; however, there is wide variability in reported birth dose coverage, with global coverage at only 42%. In this review, we outline the global trends in hepatitis B vaccination coverage and the impact of hepatitis B vaccination on HCC incidence and discuss the challenges and enabling factors for achieving WHO 2030 hepatitis B vaccination coverage targets.
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页数:16
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