Clinical significance of circulating tumor cells in patients with small-cell lung cancer

被引：6
|
作者：
Wang, Yu-Li [1 ]
Liu, Chun-Hua [2 ]
Li, Jing [3 ]
Ma, Xiao-Ping [3 ]
Gong, Ping [3 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Sch, Tongji Hosp, Dept Oncol, Wuhan, Peoples R China
[2] Peoples Hosp Xinjiang Uygyr Autonomous Reg, Dept Radiat Oncol, Uygyr, Peoples R China
[3] Shihezi Univ, Sch Med, Affiliated Hosp 1, Dept Oncol, 107 North Two Rd, Shihezi 832008, Peoples R China
来源：
TUMORI JOURNAL | 2017年 / 103卷 / 03期
关键词：
Circulating tumor cells; Clinical characteristics; Prognosis; Progression-free survival; Small-cell lung cancer; METASTATIC BREAST-CANCER; PERIPHERAL-BLOOD; SURVIVAL; PROGRESSION; END;
D O I：
10.5301/tj.5000601
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: This study investigated the correlation of the presence of circulating tumor cells (CTCs) with clinical characteristics, and the predictive value of CTCs for progression-free survival (PFS) in patients with small-cell lung cancer (SCLC). Methods: Samples were obtained from 42 patients with SCLC before and after the first cycle of chemotherapy. CTCs were quantitated by negative immunomagnetic enrichment and immunocytochemistry using anti-CD45 and anti-pancytokeratin antibodies. Results: CTCs were positive (>= 2) in 76.19% of patients with SCLC and negative in the control group. The presence of CTCs was positively correlated with 6 clinical characteristics. PFS was 6.055 and 10.670 months for patients with >= 2 and <2 CTCs/7.5 mL of blood before chemotherapy; after chemotherapy PFS was 4.862 and 10.535 months, respectively. Conclusions: This study showed that both baseline CTC numbers and the change in CTC numbers after 1 cycle of chemotherapy are significant prognostic factors of PFS for SCLC.
引用
收藏
页码：242 / 248
页数：7
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