Inhibitory effects of Indole-3-carbinol on invasion and migration in human breast cancer cells

被引：63
|
作者：
Meng, QH [1 ]
Goldberg, ID [1 ]
Rosen, EM [1 ]
Fan, SJ [1 ]
机构：
[1] Long Isl Jewish Med Ctr, Albert Einstein Coll Med, Dept Radiat Oncol, Oncol Mol Lab, New Hyde Pk, NY 11042 USA
来源：
BREAST CANCER RESEARCH AND TREATMENT | 2000年 / 63卷 / 02期
关键词：
Indole-3-carbinol; breast cancer; invasion; migration; PTEN; E-cadherin;
D O I：
10.1023/A:1006495824158
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Indole-3-carbinol (I3C) is a promising phytochemical agent in chemoprevention of breast cancer. Our present study is the first description of I3C that significantly inhibits the cell adhesion, spreading and invasion associated with an up-regulation of PTEN (a tumor suppressor gene) and E-cadherin (a regulator of cell-cell adhesion) expression in T47-D human breast cancer cells. Therefore, I3C exhibits anti-cancer activities by suppressing breast tumor cell growth and metastatic spread. Metastatic breast cancer is a devastating problem, clinical application of I3C as a potent chemopreventive agent may be helpful in limiting breast cancer invasion and metastasis.
引用
收藏
页码：147 / 152
页数：6
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